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- W2065698909 abstract "Semaphorins signal through Plexin receptors to mediate a range of predominantly repulsive effects on axons in the developing nervous system. Semaphorin-directed repulsive turning responses of cultured Xenopus neurons can be converted to attraction by manipulating cyclic nucleotide signaling pathways. cAMP- and cGMP-dependent response conversions are observed for many families of guidance cues, but a direct molecular link between guidance receptors and cyclic nucleotides has remained elusive. Recent findings indicate that the Drosophila -inase nchoring rotein (AKAP) Nervy couples Plexin to PKA to modulate Semaphorin repulsion, suggesting a mechanism for the integration of diverse signaling inputs to the growth cone." @default.
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- W2065698909 date "2004-05-01" @default.
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- W2065698909 title "Semaphorin Signaling Unplugged" @default.
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- W2065698909 doi "https://doi.org/10.1016/s0896-6273(04)00258-2" @default.
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