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• W2065705875 startingPage "667" @default.
• W2065705875 abstract "There is considerable biologic evidence indicating that testosterone is the most important androgen in women. Testosterone production rates have been elevated in almost every virilized patient studied to date. Clinical evaluation of the hirsute patient, however, is complicated by the observation that plasma testosterone alone may not adequately reflect testosterone production. This relates to the fact that plasma androgen levels in women may be independently influenced by the rate of steroid entry into blood (production rate) as well as removal from blood (clearance). The testosterone production rate must be measured in hirsute women if a complete assessment of androgen metabolism is to be made. The origin of testosterone in normal and virilized women can best be determined by a combination of steroid kinetic studies and direct sampling of adrenal and ovarian venous effluents. In normal women about 65% of plasma testosterone is derived from plasma prehormones (androstenedione and dehydro-epiandrosterone) and 35% is apparently secreted by adrenals and ovaries. In clear-cut cases of adrenal or ovarian disease, excessive androgen production can usually be traced to the abnormal organ. In most women with idiopathic hirsutism, the ovaries, rather than the adrenals, are the most common sites of androgen oversecretion." @default.
• W2065705875 created "2016-06-24" @default.
• W2065705875 creator A5042416651 @default.
• W2065705875 creator A5045087641 @default.
• W2065705875 date "1972-07-01" @default.
• W2065705875 modified "2023-10-18" @default.
• W2065705875 title "Androgen production and metabolism in normal and virilized women" @default.
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• W2065705875 doi "https://doi.org/10.1016/0026-0495(72)90090-x" @default.
• W2065705875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4562220" @default.
• W2065705875 hasPublicationYear "1972" @default.
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