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• W2065710157 startingPage "12845" @default.
• W2065710157 abstract "LEF-1 (lymphoid enhancer-binding factor 1) is a cell type-specific member of the family of high mobility group (HMG) domain proteins that recognizes a specific nucleotide sequence in the T cell receptor (TCR) α enhancer. In this study, we extend the analysis of the DNA-binding properties of LEF-1 and examine their contributions to the regulation of gene expression. We find that LEF-1, like nonspecific HMG-domain proteins, can interact with irregular DNA structures such as four-way junctions, albeit with lower efficiency than with specific duplex DNA. We also show by a phasing analysis that the LEF-induced DNA bend is directed toward the major groove. In addition, we find that the interaction of LEF-1 with a specific binding site in circular DNA changes the linking number of DNA and unwinds the double helix. Finally, we identified two nucleotides in the LEF-1-binding site that are important for protein-induced DNA bending. Mutations of these nucleotides decrease both the extent of DNA bending and the transactivation of the TCRα enhancer by LEF-1, suggesting a contribution of protein-induced DNA bending to the function of TCRα enhancer." @default.
• W2065710157 created "2016-06-24" @default.
• W2065710157 creator A5022682784 @default.
• W2065710157 creator A5040412322 @default.
• W2065710157 creator A5081242986 @default.
• W2065710157 date "1997-11-25" @default.
• W2065710157 modified "2023-09-29" @default.
• W2065710157 title "Functional analysis of DNA bending and unwinding by the high mobility group domain of LEF-1" @default.
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• W2065710157 doi "https://doi.org/10.1073/pnas.94.24.12845" @default.
• W2065710157 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/24226" @default.
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