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- W2065720900 abstract "Background: Oxyntomodulin (OXM 1–37 ) is an anorectic gut-secreting peptide with a promise to treat obesity, but its needle-free delivery has yet to be successful. Results: Pulmonary delivery of OXM 1–37 , but not its C-terminal octapeptides, caused dose-related, transient 4–6 h food intake suppression in rats. At 0.5 mg/kg, its 30–38% food intake suppression led to 46% reduction in body weight gain by day 8. Its lung absorption was fast, elevating the systemic level rapidly, yet the bioavailability was low at 13%. In the brain, twofold neuronal c-fos activation was seen in the hypothalamus arcuate nucleus and brainstem area postrema. Conclusion: Pulmonary delivery is a promising needle-free systemic delivery option for OXM 1–37 to treat obesity, as enabling effective lung absorption and brain interaction." @default.
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- W2065720900 date "2015-04-01" @default.
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- W2065720900 title "Pulmonary delivery of anorectic oxyntomodulin in rats: food intake suppression, reduced body weight gain and pharmacokinetics" @default.
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- W2065720900 doi "https://doi.org/10.4155/tde.14.117" @default.
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