Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065733721> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2065733721 endingPage "250" @default.
- W2065733721 startingPage "245" @default.
- W2065733721 abstract "Summary: In vitro and in vivo effects of trimethoprim on folate metabolism have been studied in patients with normoblastic and megaloblastic haemopoiesis. In concentrations achieved in the plasma on standard dosages of trimethoprim, no significant disturbance of folate metabolism in normal bone mar-row was detectable, either in vitro or in vivo. In vitro, higher concentrations produced abnormalities of folate metabolism which were partially corrected by pteroylglutamic acid (PGA) and completely corrected by tetrahydrofolic acid (THF). This suggested competitive inhibition of dihydrofolate reductase (DHR) by the trimethoprim. In vitro, in vitamin B12 or folatedeficient marrows, trimethoprim at therapeutic concentrations caused a further deterioration of the defective deoxyribonucleic acid (DNA)-thymine synthesis which appropriate haematinics failed to correct. In vivo studies after a standard course of trimethoprim con-firmed this effect. These studies support previous claims that many of the haemopoietic side-effects of trimethoprim are the result of the potentiation of defective DNA-thymine synthesis in situations of pre-existing folate or vitamin B12 deficiency." @default.
- W2065733721 created "2016-06-24" @default.
- W2065733721 creator A5036962005 @default.
- W2065733721 creator A5062543380 @default.
- W2065733721 creator A5063995711 @default.
- W2065733721 date "1973-06-01" @default.
- W2065733721 modified "2023-10-04" @default.
- W2065733721 title "Effect of Trimethoprim on Folate Metabolism in Human Bone Marrow" @default.
- W2065733721 cites W152477947 @default.
- W2065733721 cites W1907039156 @default.
- W2065733721 cites W1975849829 @default.
- W2065733721 cites W1992407070 @default.
- W2065733721 cites W2014131513 @default.
- W2065733721 cites W2020499208 @default.
- W2065733721 cites W2022533437 @default.
- W2065733721 cites W2034222878 @default.
- W2065733721 cites W2049391682 @default.
- W2065733721 cites W2052062459 @default.
- W2065733721 cites W2053679996 @default.
- W2065733721 cites W2062850121 @default.
- W2065733721 cites W2087868966 @default.
- W2065733721 cites W2090328172 @default.
- W2065733721 cites W2100105519 @default.
- W2065733721 cites W2407520403 @default.
- W2065733721 cites W2410347822 @default.
- W2065733721 cites W2411481514 @default.
- W2065733721 cites W4230014359 @default.
- W2065733721 cites W66642996 @default.
- W2065733721 doi "https://doi.org/10.1111/j.1445-5994.1973.tb03089.x" @default.
- W2065733721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4517220" @default.
- W2065733721 hasPublicationYear "1973" @default.
- W2065733721 type Work @default.
- W2065733721 sameAs 2065733721 @default.
- W2065733721 citedByCount "20" @default.
- W2065733721 crossrefType "journal-article" @default.
- W2065733721 hasAuthorship W2065733721A5036962005 @default.
- W2065733721 hasAuthorship W2065733721A5062543380 @default.
- W2065733721 hasAuthorship W2065733721A5063995711 @default.
- W2065733721 hasConcept C126322002 @default.
- W2065733721 hasConcept C202751555 @default.
- W2065733721 hasConcept C207001950 @default.
- W2065733721 hasConcept C2776858809 @default.
- W2065733721 hasConcept C2779405478 @default.
- W2065733721 hasConcept C2779750884 @default.
- W2065733721 hasConcept C2780728791 @default.
- W2065733721 hasConcept C2780829489 @default.
- W2065733721 hasConcept C2781059491 @default.
- W2065733721 hasConcept C2781320022 @default.
- W2065733721 hasConcept C501593827 @default.
- W2065733721 hasConcept C54355233 @default.
- W2065733721 hasConcept C552990157 @default.
- W2065733721 hasConcept C55493867 @default.
- W2065733721 hasConcept C62231903 @default.
- W2065733721 hasConcept C71924100 @default.
- W2065733721 hasConcept C86803240 @default.
- W2065733721 hasConcept C98274493 @default.
- W2065733721 hasConceptScore W2065733721C126322002 @default.
- W2065733721 hasConceptScore W2065733721C202751555 @default.
- W2065733721 hasConceptScore W2065733721C207001950 @default.
- W2065733721 hasConceptScore W2065733721C2776858809 @default.
- W2065733721 hasConceptScore W2065733721C2779405478 @default.
- W2065733721 hasConceptScore W2065733721C2779750884 @default.
- W2065733721 hasConceptScore W2065733721C2780728791 @default.
- W2065733721 hasConceptScore W2065733721C2780829489 @default.
- W2065733721 hasConceptScore W2065733721C2781059491 @default.
- W2065733721 hasConceptScore W2065733721C2781320022 @default.
- W2065733721 hasConceptScore W2065733721C501593827 @default.
- W2065733721 hasConceptScore W2065733721C54355233 @default.
- W2065733721 hasConceptScore W2065733721C552990157 @default.
- W2065733721 hasConceptScore W2065733721C55493867 @default.
- W2065733721 hasConceptScore W2065733721C62231903 @default.
- W2065733721 hasConceptScore W2065733721C71924100 @default.
- W2065733721 hasConceptScore W2065733721C86803240 @default.
- W2065733721 hasConceptScore W2065733721C98274493 @default.
- W2065733721 hasIssue "3" @default.
- W2065733721 hasLocation W20657337211 @default.
- W2065733721 hasLocation W20657337212 @default.
- W2065733721 hasOpenAccess W2065733721 @default.
- W2065733721 hasPrimaryLocation W20657337211 @default.
- W2065733721 hasRelatedWork W1760004350 @default.
- W2065733721 hasRelatedWork W1970602404 @default.
- W2065733721 hasRelatedWork W1991676504 @default.
- W2065733721 hasRelatedWork W2035747340 @default.
- W2065733721 hasRelatedWork W2065733721 @default.
- W2065733721 hasRelatedWork W2067512829 @default.
- W2065733721 hasRelatedWork W2123468777 @default.
- W2065733721 hasRelatedWork W2349067141 @default.
- W2065733721 hasRelatedWork W2418236305 @default.
- W2065733721 hasRelatedWork W221467567 @default.
- W2065733721 hasVolume "3" @default.
- W2065733721 isParatext "false" @default.
- W2065733721 isRetracted "false" @default.
- W2065733721 magId "2065733721" @default.
- W2065733721 workType "article" @default.