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• W2065751451 abstract "4H-1,4-oxazines were designed as transthyretin (TTR) amyloid fibril inhibitors based on an analysis of the interactions between known small molecule inhibitors and TTR by molecular docking. A series of 2,4,6-triaryl-4H-1,4-oxazines was synthesized by the cyclization of N,N-bis(phenacyl)anilines with POCl3 in pyridine. Inhibition of TTR amyloid fibril was evaluated by a fibril formation assay. The results indicate that 4H-1,4-oxazines significantly inhibit TTR amyloid fibril at a concentration of 7.2 μM." @default.
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• W2065751451 date "2013-01-01" @default.
• W2065751451 modified "2023-10-18" @default.
• W2065751451 title "Synthesis of 4H-1,4-oxazines as transthyretin amyloid fibril inhibitors" @default.
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• W2065751451 doi "https://doi.org/10.1039/c3ob40377g" @default.
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