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• W2065765250 abstract "To study the antitumor activity of the combination immunotherapy with interleukin-12 (IL-12) and granulocyte-macrophage colony-stimulating factor (GM-CSF), a murine MmB 16 melanoma tumor model was used. Seven days after inoculation of MmB 16 melanoma cells into the footpad of the right hind limb, mice were treated with IL-12 and/or GM-CSF administered intratumorally for 7 consecutive days. IL-12 used both at a high (1 microg) and at a low (0.01 microg) dose per day produced retardation of tumor growth, although neither treatment resulted in any significant prolongation of the survival of tumor-bearing mice. GM-CSF did not by itself exert antitumor activity in this model; however, it potentiated antitumor effects of IL-12. In particular, survival of tumor-bearing mice treated with IL-12 (0.01 microg per day) and GM-CSF was significantly prolonged compared with that in mice treated with either IL-12 or GM-CSF alone." @default.
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• W2065765250 date "1998-01-01" @default.
• W2065765250 modified "2023-10-10" @default.
• W2065765250 title "Granulocyte-Macrophage Colony-Stimulating Factor Potentiates Antitumor Activity of Interleukin-12 in Melanoma Model in Mice" @default.
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• W2065765250 doi "https://doi.org/10.1159/000029978" @default.
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