Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065779229> ?p ?o ?g. }
- W2065779229 endingPage "1182" @default.
- W2065779229 startingPage "1173" @default.
- W2065779229 abstract "The transcription factor HIF is induced in response to hypoxic stress, TCR activation and cytokines. Goldrath and colleagues show that HIF signaling enhances CTL effector responses and can render cells refractory to immune exhaustion. Cytolytic activity by CD8+ cytotoxic T lymphocytes (CTLs) is a powerful strategy for the elimination of intracellular pathogens and tumor cells. The destructive capacity of CTLs is progressively dampened during chronic infection, yet the environmental cues and molecular pathways that influence immunological 'exhaustion' remain unclear. Here we found that CTL immunity was regulated by the central transcriptional response to hypoxia, which is controlled in part by hypoxia-inducible factors (HIFs) and the von Hippel–Lindau tumor suppressor VHL. Loss of VHL, the main negative regulator of HIFs, led to lethal CTL-mediated immunopathology during chronic infection, and VHL-deficient CTLs displayed enhanced control of persistent viral infection and neoplastic growth. We found that HIFs and oxygen influenced the expression of pivotal transcription, effector and costimulatory-inhibitory molecules of CTLs, which was relevant to strategies that promote the clearance of viruses and tumors." @default.
- W2065779229 created "2016-06-24" @default.
- W2065779229 creator A5000205436 @default.
- W2065779229 creator A5027663750 @default.
- W2065779229 creator A5032052445 @default.
- W2065779229 creator A5033578999 @default.
- W2065779229 creator A5037823265 @default.
- W2065779229 creator A5055310419 @default.
- W2065779229 creator A5071427508 @default.
- W2065779229 creator A5079400625 @default.
- W2065779229 date "2013-09-29" @default.
- W2065779229 modified "2023-10-16" @default.
- W2065779229 title "Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen" @default.
- W2065779229 cites W1560312836 @default.
- W2065779229 cites W1578040179 @default.
- W2065779229 cites W1630171124 @default.
- W2065779229 cites W1888121068 @default.
- W2065779229 cites W1974842026 @default.
- W2065779229 cites W1980992966 @default.
- W2065779229 cites W1981253971 @default.
- W2065779229 cites W1981291019 @default.
- W2065779229 cites W1985294654 @default.
- W2065779229 cites W1993324234 @default.
- W2065779229 cites W1994257755 @default.
- W2065779229 cites W2014245338 @default.
- W2065779229 cites W2015992862 @default.
- W2065779229 cites W2020823643 @default.
- W2065779229 cites W2021947467 @default.
- W2065779229 cites W2032917789 @default.
- W2065779229 cites W2040080235 @default.
- W2065779229 cites W2041061869 @default.
- W2065779229 cites W2041143310 @default.
- W2065779229 cites W2043931994 @default.
- W2065779229 cites W2044257922 @default.
- W2065779229 cites W2060104085 @default.
- W2065779229 cites W2061899137 @default.
- W2065779229 cites W2068555261 @default.
- W2065779229 cites W2077116159 @default.
- W2065779229 cites W2077940506 @default.
- W2065779229 cites W2084293070 @default.
- W2065779229 cites W2089601496 @default.
- W2065779229 cites W2093776019 @default.
- W2065779229 cites W2097855813 @default.
- W2065779229 cites W2099468505 @default.
- W2065779229 cites W2104966044 @default.
- W2065779229 cites W2105697998 @default.
- W2065779229 cites W2105922971 @default.
- W2065779229 cites W2109492293 @default.
- W2065779229 cites W2112337731 @default.
- W2065779229 cites W2119896120 @default.
- W2065779229 cites W2129321174 @default.
- W2065779229 cites W2134053452 @default.
- W2065779229 cites W2135034560 @default.
- W2065779229 cites W2135153698 @default.
- W2065779229 cites W2140237734 @default.
- W2065779229 cites W2140594539 @default.
- W2065779229 cites W2149472502 @default.
- W2065779229 cites W2162873738 @default.
- W2065779229 cites W2163001100 @default.
- W2065779229 cites W2164164239 @default.
- W2065779229 cites W2168066272 @default.
- W2065779229 cites W2592935721 @default.
- W2065779229 cites W4239056782 @default.
- W2065779229 doi "https://doi.org/10.1038/ni.2714" @default.
- W2065779229 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3977965" @default.
- W2065779229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24076634" @default.
- W2065779229 hasPublicationYear "2013" @default.
- W2065779229 type Work @default.
- W2065779229 sameAs 2065779229 @default.
- W2065779229 citedByCount "472" @default.
- W2065779229 countsByYear W20657792292013 @default.
- W2065779229 countsByYear W20657792292014 @default.
- W2065779229 countsByYear W20657792292015 @default.
- W2065779229 countsByYear W20657792292016 @default.
- W2065779229 countsByYear W20657792292017 @default.
- W2065779229 countsByYear W20657792292018 @default.
- W2065779229 countsByYear W20657792292019 @default.
- W2065779229 countsByYear W20657792292020 @default.
- W2065779229 countsByYear W20657792292021 @default.
- W2065779229 countsByYear W20657792292022 @default.
- W2065779229 countsByYear W20657792292023 @default.
- W2065779229 crossrefType "journal-article" @default.
- W2065779229 hasAuthorship W2065779229A5000205436 @default.
- W2065779229 hasAuthorship W2065779229A5027663750 @default.
- W2065779229 hasAuthorship W2065779229A5032052445 @default.
- W2065779229 hasAuthorship W2065779229A5033578999 @default.
- W2065779229 hasAuthorship W2065779229A5037823265 @default.
- W2065779229 hasAuthorship W2065779229A5055310419 @default.
- W2065779229 hasAuthorship W2065779229A5071427508 @default.
- W2065779229 hasAuthorship W2065779229A5079400625 @default.
- W2065779229 hasBestOaLocation W20657792292 @default.
- W2065779229 hasConcept C104317684 @default.
- W2065779229 hasConcept C147969180 @default.
- W2065779229 hasConcept C154317977 @default.
- W2065779229 hasConcept C167672396 @default.
- W2065779229 hasConcept C193419808 @default.
- W2065779229 hasConcept C202751555 @default.
- W2065779229 hasConcept C203014093 @default.