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- W2065782017 abstract "Gene transcription occurs on a nucleosomal template known as chromatin. The recruitment of the transcriptional regulators and the transcription machinery to promoter chromatin is coordinated by a genetic code on the DNA and an epigenetic code on the histone proteins. Chromatin is not a stable environment; rather, the histones, the transcription regulatory proteins and the enzymes that modify and mobilise nucleosomes are in a dynamic state. Thus, at any one time, the factors associated with a region will cooperate or compete to change the rate of inter-conversion between permissive and non-permissive chromatin states, leading to activation or repression of transcription. Here, new concepts such as dynamic nucleosomes and a dynamic histone code in gene transcription are explored." @default.
- W2065782017 created "2016-06-24" @default.
- W2065782017 creator A5048360717 @default.
- W2065782017 date "2006-06-01" @default.
- W2065782017 modified "2023-09-23" @default.
- W2065782017 title "Dynamic nucleosomes and gene transcription" @default.
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- W2065782017 doi "https://doi.org/10.1016/j.tig.2006.03.008" @default.
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