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- W2065783376 abstract "Background: Although endoscopic ultrasound guided fine needle aspiration (EUS-FNA) is regarded as the procedure of choice for the tissue diagnosis of pancreatic cancer, few studies have shown whether this practice influences patient outcomes. Also, there are still concerns regarding the safety of EUS-FNA particularly in the elderly, as well as the risk for tumor seeding. Aim: To assess the survival of patients with unresectable pancreatic cancer in relation to whether or not they underwent non-surgical biopsy of their primary tumor. Methods: We used the U.S. National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) database to identify a cohort of patients diagnosed with distant pancreatic cancer between 1991 and 2000, who underwent radiation therapy. We excluded those who had cancer-directed surgery. Results: There was no difference in 3-year relative cumulative survival between patients who underwent microscopic confirmation and those who did not (Table). There was also no difference in 3-year survival among patients who underwent microscopic confirmation, according to method used (histology, 4.3% and exfoliative cytology without histology, 3.1%). Conclusion: Non-surgical biopsy did not appear to adversely affect survival among patients with advanced pancreatic cancer. The data also do not support any negative impact on outcome with the introduction of EUS-FNA in the United States. Future studies should include information on comorbidity, as well as the impact of tissue diagnosis obtained by EUS-FNA on end of life care." @default.
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- W2065783376 date "2005-04-01" @default.
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- W2065783376 title "Impact of Tissue Diagnosis on Survival of Patients with Advanced Pancreatic Cancer: A Population-Based Study" @default.
- W2065783376 doi "https://doi.org/10.1016/s0016-5107(05)01443-4" @default.
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