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- W2065790767 abstract "Lymphokine-activated killer cells (LAK) are functionally defined by their ability to mediate the MHC-unrestricted lysis of a range of tumor targets, while sparing normal cells. They can also lyse TNP-modified normal syngeneic lymphoblasts. We show here that lysis of TNP-modified targets is mediated by CD8+ LAK in a self-MHC-restricted manner, whereas lysis of tumor targets is largely by CD8− LAK and is MHC-unrestricted. LAK generated from the immune-deficient strains Balb/c nude and C.B-17 scid lyse tumor targets as effectively as LAK from normal mice but do not lyse TNP-modified normal targets. Further, lysis of TNP-modified targets, but not tumors, can be inhibited by antibody to the T cell receptor complex. These experiments strongly suggest that recognition of TNP-modified targets is not accomplished by the same mechanism as that of tumors. Rather, they are consistent with recognition of TNP-modified targets by CD8+ LAK cells being mediated via recognition through the T cell receptor." @default.
- W2065790767 created "2016-06-24" @default.
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- W2065790767 date "1991-01-01" @default.
- W2065790767 modified "2023-10-16" @default.
- W2065790767 title "Heterogeneity of the lymphokine-activated killer cell phenotype" @default.
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- W2065790767 doi "https://doi.org/10.1016/0008-8749(91)90016-5" @default.
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