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- W2065791710 endingPage "3897" @default.
- W2065791710 startingPage "3868" @default.
- W2065791710 abstract "The angiotensin II (Ang II) type 1 and type 2 receptors (AT1R and AT2R) orchestrate an array of biological processes that regulate human health. Aberrant function of these receptors triggers pathophysiological responses that can ultimately lead to death. Therefore, it is important to design and synthesize compounds that affect beneficially these two receptors. Cardiovascular disease, which is attributed to the overactivation of the vasoactive peptide hormone Αng II, can now be treated with commercial AT1R antagonists. Herein, recent achievements in rational drug design and synthesis of molecules acting on the two AT receptors are reviewed. Quantitative structure activity relationships (QSAR) and molecular modeling on the two receptors aim to assist the search for new active compounds. As AT1R and AT2R are GPCRs and drug action is localized in the transmembrane region the role of membrane bilayers is exploited. The future perspectives in this field are outlined. Tremendous progress in the field is expected if the two receptors are crystallized, as this will assist the structure based screening of the chemical space and lead to new potent therapeutic agents in cardiovascular and other diseases." @default.
- W2065791710 created "2016-06-24" @default.
- W2065791710 creator A5009553458 @default.
- W2065791710 creator A5024188443 @default.
- W2065791710 creator A5090891795 @default.
- W2065791710 date "2015-03-02" @default.
- W2065791710 modified "2023-10-06" @default.
- W2065791710 title "Rational Drug Design and Synthesis of Molecules Targeting the Angiotensin II Type 1 and Type 2 Receptors" @default.
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