Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065793054> ?p ?o ?g. }
Showing items 1 to 42 of
42
with 100 items per page.
- W2065793054 abstract "A team of researchers has suggested a way to undo the cross-linking of collagen that occurs with aging and is accelerated in diabetes. Their work validates a model pathway proposed for formation of the covalent, glucose-derived cross-links and opens the way for design of drugs to reverse damaging side effects of diabetes. The team includes scientists from the Picower Institute for Medical Research and North Shore University Hospital, both in Manhasset, N.Y.; Alteon Inc., Ramsey, N.J.; and the University of Minnesota School of Medicine, Minneapolis [ Nature , 382, 275 (1996)]. Glucose latches onto tissue proteins by coupling its carbonyl group to a side-chain amino group such as lysine's. Over time, these adducts form structures called advanced glycation end products (AGEs) that covalently bind other proteins, including lowdensity lipoproteins (LDLs). These cross-linked proteins stiffen connective tissue and lead to retinal damage and impaired kidney function. Buildup of AGE-bound LDLs in the bloodstream i..." @default.
- W2065793054 created "2016-06-24" @default.
- W2065793054 creator A5070806998 @default.
- W2065793054 date "1996-07-22" @default.
- W2065793054 modified "2023-09-26" @default.
- W2065793054 title "PROTEIN CROSS-LINKING" @default.
- W2065793054 doi "https://doi.org/10.1021/cen-v074n030.p009" @default.
- W2065793054 hasPublicationYear "1996" @default.
- W2065793054 type Work @default.
- W2065793054 sameAs 2065793054 @default.
- W2065793054 citedByCount "2" @default.
- W2065793054 countsByYear W20657930542013 @default.
- W2065793054 crossrefType "journal-article" @default.
- W2065793054 hasAuthorship W2065793054A5070806998 @default.
- W2065793054 hasConcept C134018914 @default.
- W2065793054 hasConcept C147990577 @default.
- W2065793054 hasConcept C178790620 @default.
- W2065793054 hasConcept C180577832 @default.
- W2065793054 hasConcept C185592680 @default.
- W2065793054 hasConcept C2776016237 @default.
- W2065793054 hasConcept C515207424 @default.
- W2065793054 hasConcept C55493867 @default.
- W2065793054 hasConcept C555293320 @default.
- W2065793054 hasConcept C71924100 @default.
- W2065793054 hasConceptScore W2065793054C134018914 @default.
- W2065793054 hasConceptScore W2065793054C147990577 @default.
- W2065793054 hasConceptScore W2065793054C178790620 @default.
- W2065793054 hasConceptScore W2065793054C180577832 @default.
- W2065793054 hasConceptScore W2065793054C185592680 @default.
- W2065793054 hasConceptScore W2065793054C2776016237 @default.
- W2065793054 hasConceptScore W2065793054C515207424 @default.
- W2065793054 hasConceptScore W2065793054C55493867 @default.
- W2065793054 hasConceptScore W2065793054C555293320 @default.
- W2065793054 hasConceptScore W2065793054C71924100 @default.
- W2065793054 hasLocation W20657930541 @default.
- W2065793054 hasOpenAccess W2065793054 @default.
- W2065793054 hasPrimaryLocation W20657930541 @default.
- W2065793054 hasRelatedWork W2025748287 @default.
- W2065793054 isParatext "false" @default.
- W2065793054 isRetracted "false" @default.
- W2065793054 magId "2065793054" @default.
- W2065793054 workType "article" @default.