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• W2065793642 abstract "Limited cutaneous systemic sclerosis (lSSc) or CREST syndrome is sometimes complicated by primary biliary cirrhosis (PBC). To characterize the clinical and immunological features of patients with SSc overlapping PBC (SSc-PBC), the clinical and laboratory data of 11 SSc-PBC were studied. Since all of the SSc-PBC were lSSc, the features of SSc-PBC were compared with those of 266 patients with lSSc alone. The sera from SSc-PBC showed a significantly higher positivity for anti-centromere antibody (ACA) (p < 0.0005) and higher reactivity to centromere protein-C. Although SSc-PBC more frequently exhibited calcinosis and telangiectasia (p < 0.05), there was no statistical difference in other features of CREST syndrome. There was no statistical difference in other scleroderma-related features either. SSc-PBC were more frequently complicated with Sjögren syndrome (p < 0.05). The most prominent feature of SSc-PBC was a higher incidence of ACA than in lSSc alone." @default.
• W2065793642 created "2016-06-24" @default.
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• W2065793642 date "1999-01-01" @default.
• W2065793642 modified "2023-10-18" @default.
• W2065793642 title "Clinical and Immunological Characterization of Patients with Systemic Sclerosis Overlapping Primary Biliary Cirrhosis: A Comparison with Patients with Systemic Sclerosis Alone" @default.
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• W2065793642 doi "https://doi.org/10.1111/j.1346-8138.1999.tb03503.x" @default.
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