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• W2065797404 abstract "Abstract Cultured mouse cerebellar granule cells differ from their rat counterparts in that they survive well when grown in non‐depolarising medium (5 mM K + ). However, when chronically stimulated by added glutamate agonists, including (RS)α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA), rat cerebellar granule cells also survive well in non‐depolarising medium. We hypothesised that the relatively good survival of mouse cerebellar granule cells in the absence of added glutamate agonists might reflect AMPA receptors resistant to desensitisation. These receptors might be stimulated by endogenous glutamate. We tested this hypothesis by comparing cultured mouse and rat cerebellar granule cells grown in depolarising (25 mM K + ) and non‐depolarising (5 mM K + ) medium. We studied the AMPA‐induced increase in intracellular Ca 2+ concentration ([Ca 2+ ] i ), using the fluorescent Ca 2+ chelator, Fluo‐3, and the relative concentrations of mRNAs for the four AMPA receptor subunits, GluR1–4. GluR1–4 mRNAs were measured by restriction enzyme analysis of a PCR product containing cDNA with a composition proportional to the four subunit mRNAs. We found that the [Ca 2+ ] i ‐response to AMPA receptor activation in cultured cerebellar granule cells is determined mainly by the desensitisation properties of the AMPA receptors rather than by their ion permeability. We also found that mouse cerebellar granule cells express AMPA receptors which are more resistant to desensitisation than the corresponding rat AMPA receptors. Thus, relatively slow AMPA receptor desensitisation kinetics may contribute to the survival of mouse cerebellar granule cells in non‐depolarising medium." @default.
• W2065797404 created "2016-06-24" @default.
• W2065797404 creator A5047211233 @default.
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• W2065797404 date "2000-02-01" @default.
• W2065797404 modified "2023-09-26" @default.
• W2065797404 title "AMPA receptor subunit mRNAs and intracellular [Ca²⁺] in cultured mouse and rat cerebellar granule cells" @default.
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• W2065797404 doi "https://doi.org/10.1016/s0736-5748(99)00105-7" @default.
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