Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065798773> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2065798773 endingPage "2915" @default.
- W2065798773 startingPage "2905" @default.
- W2065798773 abstract "Adjuvant chemotherapy has changed dramatically in the last decades. Anthracycline-/Taxane-based and dose-dense chemotherapy regimens improved survival in node positive breast cancer. This study tries to answer the following questions:This is a German multi-centre (17 participating hospitals all certified as breast cancer centres) retrospective cohort study. We included patients that received CMF-like (CMF) (n=1308), Anthracycline-based (A) (1046), Anthracycline-Taxane-based (AT) (1110) and dose-dense chemotherapy (DD) (213) into this analysis.In case of N0 and 1-3 pos LN we did not observe statistically significant differences in overall (OS) and disease-free survival (DFS) between CMF/A/AT and (for 1-3 pos LN) DD. In the group of 4-10 pos LN we observe an improvement by the use of AT-based chemotherapy, which cannot further be improved by DD chemotherapy. However in the highest risk group, defined as ⩾11 pos LN, we observed a statistically significant improvement in survival by the use of DD chemotherapy. Also a statistically slightly non-significant trend towards improvement of survival parameters by the use of DD compared to AT chemotherapy could be observed. Only for G3 subtypes we could observe a survival benefit for DD. These results remain consistent after exclusion of non-guideline adherent patients (surgery, radiotherapy and endocrine therapy) in order to reduce the bias of guideline violations in other adjuvant treatment modalities.DD chemotherapy is associated with improved survival parameters in patients with ⩾11 positive LN." @default.
- W2065798773 created "2016-06-24" @default.
- W2065798773 creator A5044504864 @default.
- W2065798773 creator A5047408505 @default.
- W2065798773 creator A5048483934 @default.
- W2065798773 creator A5057393976 @default.
- W2065798773 creator A5062888424 @default.
- W2065798773 creator A5073426374 @default.
- W2065798773 creator A5079917751 @default.
- W2065798773 date "2014-11-01" @default.
- W2065798773 modified "2023-10-18" @default.
- W2065798773 title "Assessing the impact of CMF-like/Anthracycline-based/Anthracycline-Taxane-based/dose-dense chemotherapy in dependency of positive axillary lymph nodes/hormone receptor-status/grading/T-stage on survival – A retrospective multi-centre cohort study of 3677 patients receiving adjuvant chemotherapy" @default.
- W2065798773 cites W1701849548 @default.
- W2065798773 cites W1979640793 @default.
- W2065798773 cites W2005108069 @default.
- W2065798773 cites W2022719572 @default.
- W2065798773 cites W2040881274 @default.
- W2065798773 cites W2066636335 @default.
- W2065798773 cites W2075213874 @default.
- W2065798773 cites W2092587002 @default.
- W2065798773 cites W2101760255 @default.
- W2065798773 cites W2109887943 @default.
- W2065798773 cites W2125955497 @default.
- W2065798773 cites W2129623087 @default.
- W2065798773 cites W2164214273 @default.
- W2065798773 cites W2166572860 @default.
- W2065798773 doi "https://doi.org/10.1016/j.ejca.2014.08.015" @default.
- W2065798773 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25239681" @default.
- W2065798773 hasPublicationYear "2014" @default.
- W2065798773 type Work @default.
- W2065798773 sameAs 2065798773 @default.
- W2065798773 citedByCount "5" @default.
- W2065798773 countsByYear W20657987732015 @default.
- W2065798773 countsByYear W20657987732017 @default.
- W2065798773 countsByYear W20657987732020 @default.
- W2065798773 crossrefType "journal-article" @default.
- W2065798773 hasAuthorship W2065798773A5044504864 @default.
- W2065798773 hasAuthorship W2065798773A5047408505 @default.
- W2065798773 hasAuthorship W2065798773A5048483934 @default.
- W2065798773 hasAuthorship W2065798773A5057393976 @default.
- W2065798773 hasAuthorship W2065798773A5062888424 @default.
- W2065798773 hasAuthorship W2065798773A5073426374 @default.
- W2065798773 hasAuthorship W2065798773A5079917751 @default.
- W2065798773 hasConcept C121608353 @default.
- W2065798773 hasConcept C126322002 @default.
- W2065798773 hasConcept C143998085 @default.
- W2065798773 hasConcept C167135981 @default.
- W2065798773 hasConcept C2776694085 @default.
- W2065798773 hasConcept C2776802502 @default.
- W2065798773 hasConcept C2777511904 @default.
- W2065798773 hasConcept C530470458 @default.
- W2065798773 hasConcept C71924100 @default.
- W2065798773 hasConceptScore W2065798773C121608353 @default.
- W2065798773 hasConceptScore W2065798773C126322002 @default.
- W2065798773 hasConceptScore W2065798773C143998085 @default.
- W2065798773 hasConceptScore W2065798773C167135981 @default.
- W2065798773 hasConceptScore W2065798773C2776694085 @default.
- W2065798773 hasConceptScore W2065798773C2776802502 @default.
- W2065798773 hasConceptScore W2065798773C2777511904 @default.
- W2065798773 hasConceptScore W2065798773C530470458 @default.
- W2065798773 hasConceptScore W2065798773C71924100 @default.
- W2065798773 hasFunder F4320321114 @default.
- W2065798773 hasIssue "17" @default.
- W2065798773 hasLocation W20657987731 @default.
- W2065798773 hasLocation W20657987732 @default.
- W2065798773 hasOpenAccess W2065798773 @default.
- W2065798773 hasPrimaryLocation W20657987731 @default.
- W2065798773 hasRelatedWork W2013223170 @default.
- W2065798773 hasRelatedWork W2020150632 @default.
- W2065798773 hasRelatedWork W2328465541 @default.
- W2065798773 hasRelatedWork W2331329572 @default.
- W2065798773 hasRelatedWork W2586050845 @default.
- W2065798773 hasRelatedWork W2591616149 @default.
- W2065798773 hasRelatedWork W2791179561 @default.
- W2065798773 hasRelatedWork W3114061532 @default.
- W2065798773 hasRelatedWork W4212973790 @default.
- W2065798773 hasRelatedWork W757206253 @default.
- W2065798773 hasVolume "50" @default.
- W2065798773 isParatext "false" @default.
- W2065798773 isRetracted "false" @default.
- W2065798773 magId "2065798773" @default.
- W2065798773 workType "article" @default.