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- W2065804151 abstract "Ultrafiltration studies have detected the existence of a weak interaction between cimetidine and human serum albumin, a finding supported by corresponding studies with this xenobiotic and bovine serum albumin. Furthermore, the binding characteristics of the interaction with human serum albumin (4 sites, K = 630 M-1) more than suffice to account for the proportion of protein-bound drug in the serum of patients subjected to cimetidine therapy. Thus, although alpha 1-acid glycoprotein is usually regarded as the specific transporter of basic drugs, the present evidence implicates albumin as the likely binding protein for cimetidine in serum." @default.
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- W2065804151 date "1990-10-01" @default.
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- W2065804151 title "Interaction of cimetidine with human serum albumin" @default.
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- W2065804151 doi "https://doi.org/10.1016/0006-2952(90)90472-w" @default.
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