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- W2065804563 abstract "High plasma level of P-selectin is associated with the development of venous thromboembolism (VTE). Furthermore, supplementation of vitamin D could decrease thrombotic events. Hence, this study was designed to examine whether the administration of vitamin D can influence the plasma level of P-selectin in patients with VTE. In the randomized controlled trial, 60 patients with confirmed acute deep vein thrombosis and/or pulmonary embolism (PE) were randomized into the intervention (n = 20) and control (n = 40) groups. The intervention arm was given an intramuscular single dose of 300 000 IU vitamin D 3 . Plasma level of 25-hydroxy vitamin D, P-selectin, and high-sensitive C-reactive protein (hs-CRP) was measured at baseline and 4 weeks after. The plasma level of P-selectin (95% confidence interval = −5.99 to −1.63, P = .022) and hs-CRP ( P = .024) significantly declined in vitamin D-treated group, while only hs-CRP was significantly decreased in the control group ( P = .011). However, the magnitude of these reductions was not statistically significant. This study could not support the potential benefit of the high-dose vitamin D on plasma level of P-selectin and hs-CRP in patients with VTE." @default.
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- W2065804563 date "2015-01-19" @default.
- W2065804563 modified "2023-09-29" @default.
- W2065804563 title "The Effect of High-Dose Vitamin D<sub>3</sub>on Soluble P-Selectin and hs-CRP Level in Patients With Venous Thromboembolism" @default.
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- W2065804563 doi "https://doi.org/10.1177/1076029614568715" @default.
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