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• W2065806577 abstract "A DNA molecule was designed and synthesized with three octanucleotide stretches linked by two hexakis(ethylene glycol) chains to form an intramolecular triplex in solution. The structural data obtained from a series of NMR NOESY spectra yielded interproton distances, and COSY experiments provided dihedral angle information for analysis of deoxyribose ring pucker. Using distance geometry followed by simulated annealing with restrained molecular dynamics and relaxation matrix refinement, a well-refined ensemble of conformations was calculated. Although some NOE cross-peaks involving protons of the hexakis(ethylene glycol) linker could be identified, most could not be assigned and the conformations of the linkers were not determined. The deoxyribose conformations are predominantly of the S type, except for the protonated cytosine residues in the third strand which show hybrid N and S character. Overall, the duplex part of the molecule resembles a B-DNA double helix with the third strand bound in its major groove by Hoogsteen hydrogen bonds. This structure provides a basis for comparison with triplexes containing noncanonical or nonnatural nucleotides." @default.
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• W2065806577 date "1998-03-24" @default.
• W2065806577 modified "2023-09-25" @default.
• W2065806577 title "Solution Structure of an Intramolecular DNA Triplex Linked by Hexakis(ethylene glycol) Units: d(AGAGAGAA-(EG)₆-TTCTCTCT-(EG)₆-TCTCTCTT)^," @default.
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• W2065806577 doi "https://doi.org/10.1021/bi9728102" @default.
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