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- W2065809097 abstract "A new two-site immunoenzymometric method using monoclonal antibodies was developed for measuring CK-BB mass concentrations in cerebrospinal fluid (CSF). Within- and between-assay coefficient of variation values for the method varied between 6 and 9%. Assay results are not affected by presence of sulfate and sialic acid groups on the enzyme. In comparison to catalytic activity measurements, a steady decline in the enzyme's specific activity was observed after acute head trauma. Repetitive measurements of CK-BB mass concentration in cerebrospinal fluid during the first 24 h after trauma enabled the estimation of brain lesion size. Clinical outcome of acute head trauma patients evaluated by Glasglow Outcome Scale, correlated well with cumulative CK-BB release after trauma. Also in neonates, CK-BB determinations in CSF correlated well with clinical findings." @default.
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- W2065809097 date "1990-12-01" @default.
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- W2065809097 title "Mass concentration measurements of creatine kinase BB isoenzyme as an index of brain tissue damage" @default.
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- W2065809097 doi "https://doi.org/10.1016/0009-8981(90)90244-m" @default.
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