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• W2065809403 abstract "OBJECTIVE To study the effects of long‐term combined continuous oral hormone replacement therapy (HRT) on vascular function in healthy postmenopausal women. BACKGROUND The cardiovascular effects of HRT are controversial. Improvement in vascular function is a proposed mechanism of oestrogen action but there are no long‐term controlled human trials in this area. In this study, we examined the effects of HRT on lipid profiles and vascular function, encompassing both biomechanical arterial properties [systemic arterial compliance (SAC) and pulse wave velocity (PWV)] and endothelial function [flow‐mediated vasodilation (FMD)]. METHODS In this 2‐year, double‐blind, placebo‐controlled study, 59 healthy postmenopausal women were randomized to oral combined continuous oestrogen and progesterone [Kliogest®, oestradiol (2 mg), norethisterone (1 mg)] or placebo, with end‐points measured at baseline, 6 weeks and after 6, 12 and 24 months of treatment. RESULTS Oral combined HRT reduced lipoprotein a [Lp(a)], although other lipid benefits were not observed. There were no significant changes in SAC, PWV or FMD with oral combined HRT, compared to placebo. CONCLUSION In this long‐term, randomized placebo‐controlled trial, oral continuous HRT with combined oestradiol and norethisterone in healthy postmenopausal women did not improve a spectrum of indices of arterial function compared to placebo. These results suggest that HRT might not be of cardiovascular benefit in postmenopausal women." @default.
• W2065809403 created "2016-06-24" @default.
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• W2065809403 date "2001-11-01" @default.
• W2065809403 modified "2023-10-16" @default.
• W2065809403 title "A placebo-controlled trial of long-term oral combined continuous hormone replacement therapy in postmenopausal women: effects on arterial compliance and endothelial function" @default.
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• W2065809403 doi "https://doi.org/10.1046/j.1365-2265.2001.01382.x" @default.
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