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- W2065812642 abstract "Astrocyte swelling is observed in different types of brain injury including hepatic encephalopathy (HE). This study investigates the role of astrocyte swelling on Zn2+ homeostasis in hypoosmotically treated astrocytes by using the Zn2+ indicators Newport-Green, Zinquin, and RhodZin-3. Hypoosmolarity (205 mosmol/L) led to a persistent increase of the intracellular “free” Zn2+ concentration [Zn2+]i within 15 min, which was reversible after reinstitution of normoosmolarity (305 mosmol/L). The hypoosmotic [Zn2+]i increase was abolished in the presence of the Zn2+ chelator TPEN, the NMDA receptor antagonists MK-801 and AP5, the antioxidant epigallocatechin gallate, and the nitric oxide synthase inhibitors L-NMMA and TRIM. Hypoosmolarity triggered nuclear accumulation of the metal response element-binding transcription factor MTF-1 and the specificity protein Sp1 and expression of the mRNAs encoding metallothionein and the Sp1-regulated peripheral-type benzodiazepine receptor (PBR). These effects were abolished by the Zn2+ chelator TPEN. The data suggest that astrocyte swelling affects gene expression by modulation of [Zn2+]i. Whereas Zn2+-dependent upregulation of metallothionein may help to counteract excessive astrocyte swelling and production of reactive oxygen and nitrogen oxide species, stimulation of PBR expression may augment HE development. © 2008 Wiley-Liss, Inc." @default.
- W2065812642 created "2016-06-24" @default.
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- W2065812642 date "2009-01-01" @default.
- W2065812642 modified "2023-09-26" @default.
- W2065812642 title "Hypoosmotic swelling affects zinc homeostasis in cultured rat astrocytes" @default.
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- W2065812642 doi "https://doi.org/10.1002/glia.20737" @default.
- W2065812642 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18709649" @default.
- W2065812642 hasPublicationYear "2009" @default.
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