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- W2065817813 abstract "Many experiments have been performed to evaluate the physiological role of catecholaminergic mechanisms inn gonadotropin release. The purpose of the present study was to determine the concentration of β-adrenoreceptors in the remaining (right) cerebral cortex and in right and left hypothalamic halves of hemi-decorticated female rats which exhibited elevated plasma gonadotropin levels as observed previouly. The density of β-receptors was measured using a high-affinity ligand, iodocyanopindolol (ICYP). Scatchard estimates were obtained for maximum binding (Bmaxfm,ol/mg of tissues) from pooled cerebral cortical and hypothalamic tissue of animals under several experimental conditions after hemi-decortication and sham operation. There was an increase in β-adrenoreceptor density in the remaining (right) cerebral cortex at all times examined in hemi-decorticate in comparison with the sham-operated animals (7 days, +110.9%; 21 days, +8.4%; 90 days, +22%; and 90 days plus ovariectomy, +34.8%). The number of β-adrenoreceptors in the right hypothalamic half in hemi-decorticates decreased at 21 days (-42.20%) and then increased at 90 days (+76.63%) and 90 days plus ovariectomy (+51.75%) when compared with the left hypothalamic half. At the same time there were no significant changes in the sham-operated animals when comparing the receptor density in the right and left hypothalamic halves, respectively. Thus, our results suggest a direct or indirect adrenergic pathway by which the left cortex can influence the right cortex and a crossed pathway to the contralateral hypothalamuc changing adrenergic activity which can alter the β-adrenergic receptor binding capacity in the hypothalamus." @default.
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- W2065817813 date "1986-10-01" @default.
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- W2065817813 title "Effects of unilateral decortication on β-adrenergic receptors in the remaining cortex and in the hypothalamus of female rats" @default.
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- W2065817813 doi "https://doi.org/10.1016/0006-8993(86)91213-8" @default.
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