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• W2065825519 abstract "The binding of the α 1 -adrenergic receptors antagonist, 125 I-HEAT, to membranes of nucleus tractus solitarii (NTS) regions of the brains of neurogenic hypertensive, spontaneously hypertensive (SH), and deoxycorticosterone (DOCA)/salt hypertensive rats and their respective controls was studied to quantitate the expression of α 1 -adrenergic receptors. Scatchard analysis of the binding studies revealed a 1.8-fold increase in the B max of α 1 -adrenergic receptors in NTS region membranes of SH rats when compared to their Wistar-Kyoto (WKY) control without significant difference in the K d for 125 I-HEAT. A decrease in the K d with no difference in B max of receptors 125 I-HEAT was observed in the NTS region membranes of neurogenic hypertensive rats when compared with their sham-operated controls. In contrast, comparison of the B max and K d values for 125 I-HEAT binding in NTS region membrane of the DOCA/salt hypertensive rats and its sham-operated control showed no significant differences. We suggest that alterations in baroreceptor afferent activity may be related to alterations in central α 1 -adrenergic receptors binding in SH rats and rats with neurogenic hypertension." @default.
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• W2065825519 date "1990-06-01" @default.
• W2065825519 modified "2023-09-23" @default.
• W2065825519 title "α1-Adrenergic receptors in the nucleus tractus solitarii region of rats with experimental and genetic hypertension" @default.
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• W2065825519 doi "https://doi.org/10.1016/0006-8993(90)90087-r" @default.
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