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- W2065827384 abstract "Chronic ethanol treatment (CET) produces a permanent reduction in hippocampal long-term potentiation (LTP). The CET produced reduction of LTP can be eliminated acutely by Pharmacological blockade of γ-aminobutyric acid (GABA)ergicA synaptic transmission with the specific antagonist, bicuculline methiodide. Since LTP induction is normally modulated by activation of GABAergic synaptic transmission, we hypothesized that CET reduced LTP by enhancing either postsynaptic GABAA channel function or GABA release from presynaptic terminals. In the present study, we examined the long term effects of CET on GABAA channel function by measuring the efficacy of GABA to stimulate and bicuculline to antagonize GABA-stimulated 36Cl− uptake in hippocampal and cortical membrane preparations. CET did not affect basal uptake of chloride or the efficacy or either GABA or bicuculline at the GABAA channel. We next measured the long term effects of CET on basal and stimulated GABA release. When basal and electrically-stimulated [3H]GABA release were measured in superfused hippocampal slices, stimulated release was increased by 30% in CET rats. Basal release was unaffected. Thus it appears that CET may be reducing LTP by enhancing plasticityrelated GABA release from presynaptic terminals. © 1994 Wiley-Lisa, Inc." @default.
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- W2065827384 date "1994-07-01" @default.
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- W2065827384 title "Chronic ethanol exposure enhances [3H]GABA release and does not affect GABAA receptor mediated36Cl uptake" @default.
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- W2065827384 doi "https://doi.org/10.1002/syn.890170302" @default.
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