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- W2065830801 abstract "Anemia is present in over two-thirds of patients with malignant hematological disorders. The etiology of anemia predominates from ineffective erythropoiesis from marrow infiltration, cytokine related suppression, erythropoietin suppression, and vitamin deficiency; ineffective erythropoiesis is further exacerbated by accelerated clearance due to antibody mediated hemolysis and thrombotic microangiopathy. As the anemia is chronic in nature, symptoms are generally well tolerated and often non-specific. Transfusion of red blood cells (RBCs) is a balance between providing benefit for patients while avoiding risks of transfusion. Conservative/restrictive RBC transfusion practices have shown equivalent patient outcomes compared to liberal transfusion practices, and meta-analysis has shown improved in-hospital mortality, reduced cardiac events, re-bleeding, and bacterial infections. The implications for a lower threshold for transfusion in patients with malignancies are therefore increasingly being scrutinized. Alternative management strategies for anemia with IV iron and erythropoietin stimulating agents (ESAs) should be considered in the appropriate settings." @default.
- W2065830801 created "2016-06-24" @default.
- W2065830801 creator A5030485203 @default.
- W2065830801 creator A5038567449 @default.
- W2065830801 creator A5043249165 @default.
- W2065830801 date "2015-09-01" @default.
- W2065830801 modified "2023-10-14" @default.
- W2065830801 title "Transfusions for anemia in adult and pediatric patients with malignancies" @default.
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- W2065830801 doi "https://doi.org/10.1016/j.blre.2015.02.001" @default.
- W2065830801 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7127235" @default.
- W2065830801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25796130" @default.
- W2065830801 hasPublicationYear "2015" @default.
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