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• W2065831401 endingPage "e17429" @default.
• W2065831401 startingPage "e17429" @default.
• W2065831401 abstract "Background MicroRNAs are a class of small RNAs known to regulate gene expression at the transcript level, the protein level, or both. Since microRNA binding is sequence-based but possibly structure-specific, work in this area has resulted in multiple databases storing predicted microRNA:target relationships computed using diverse algorithms. We integrate prediction databases, compare predictions to in vitro data, and use cross-database predictions to model the microRNA:transcript interactome – referred to as the micronome – to study microRNA involvement in well-known signalling pathways as well as associations with disease. We make this data freely available with a flexible user interface as our microRNA Data Integration Portal — mirDIP (http://ophid.utoronto.ca/mirDIP). Results mirDIP integrates prediction databases to elucidate accurate microRNA:target relationships. Using NAViGaTOR to produce interaction networks implicating microRNAs in literature-based, KEGG-based and Reactome-based pathways, we find these signalling pathway networks have significantly more microRNA involvement compared to chance (p<0.05), suggesting microRNAs co-target many genes in a given pathway. Further examination of the micronome shows two distinct classes of microRNAs; universe microRNAs, which are involved in many signalling pathways; and intra-pathway microRNAs, which target multiple genes within one signalling pathway. We find universe microRNAs to have more targets (p<0.0001), to be more studied (p<0.0002), and to have higher degree in the KEGG cancer pathway (p<0.0001), compared to intra-pathway microRNAs. Conclusions Our pathway-based analysis of mirDIP data suggests microRNAs are involved in intra-pathway signalling. We identify two distinct classes of microRNAs, suggesting a hierarchical organization of microRNAs co-targeting genes both within and between pathways, and implying differential involvement of universe and intra-pathway microRNAs at the disease level." @default.
• W2065831401 created "2016-06-24" @default.
• W2065831401 creator A5000800493 @default.
• W2065831401 creator A5050241516 @default.
• W2065831401 creator A5055656807 @default.
• W2065831401 creator A5064207448 @default.
• W2065831401 date "2011-02-25" @default.
• W2065831401 modified "2023-10-02" @default.
• W2065831401 title "NAViGaTing the Micronome – Using Multiple MicroRNA Prediction Databases to Identify Signalling Pathway-Associated MicroRNAs" @default.
• W2065831401 cites W144423133 @default.
• W2065831401 cites W1543796220 @default.
• W2065831401 cites W1920303762 @default.
• W2065831401 cites W1965371218 @default.
• W2065831401 cites W1967543716 @default.
• W2065831401 cites W1967633197 @default.
• W2065831401 cites W1973699456 @default.
• W2065831401 cites W1975981804 @default.
• W2065831401 cites W1978337436 @default.
• W2065831401 cites W1981711832 @default.
• W2065831401 cites W1984675364 @default.
• W2065831401 cites W1984936387 @default.
• W2065831401 cites W1988163167 @default.
• W2065831401 cites W1988224683 @default.
• W2065831401 cites W1992941735 @default.
• W2065831401 cites W1999895438 @default.
• W2065831401 cites W2006079840 @default.
• W2065831401 cites W2009886463 @default.
• W2065831401 cites W2011389479 @default.
• W2065831401 cites W2012852001 @default.
• W2065831401 cites W2022646895 @default.
• W2065831401 cites W2024000520 @default.
• W2065831401 cites W2024716296 @default.
• W2065831401 cites W2025763720 @default.
• W2065831401 cites W2026570544 @default.
• W2065831401 cites W2030083012 @default.
• W2065831401 cites W2034595398 @default.
• W2065831401 cites W2039213901 @default.
• W2065831401 cites W2040191060 @default.
• W2065831401 cites W2044285871 @default.
• W2065831401 cites W2044832480 @default.
• W2065831401 cites W2046314136 @default.
• W2065831401 cites W2050066317 @default.
• W2065831401 cites W2050869737 @default.
• W2065831401 cites W2054849588 @default.
• W2065831401 cites W2055309264 @default.
• W2065831401 cites W2059073003 @default.
• W2065831401 cites W2061174980 @default.
• W2065831401 cites W2065566217 @default.
• W2065831401 cites W2070571588 @default.
• W2065831401 cites W2075110522 @default.
• W2065831401 cites W2075168304 @default.
• W2065831401 cites W2077173862 @default.
• W2065831401 cites W2083381199 @default.
• W2065831401 cites W2087064593 @default.
• W2065831401 cites W2091082435 @default.
• W2065831401 cites W2094253263 @default.
• W2065831401 cites W2098044274 @default.
• W2065831401 cites W2103392842 @default.
• W2065831401 cites W2105274319 @default.
• W2065831401 cites W2107903949 @default.
• W2065831401 cites W2108871359 @default.
• W2065831401 cites W2109136664 @default.
• W2065831401 cites W2112192177 @default.
• W2065831401 cites W2113565103 @default.
• W2065831401 cites W2117391818 @default.
• W2065831401 cites W2117431427 @default.
• W2065831401 cites W2120456037 @default.
• W2065831401 cites W2124666089 @default.
• W2065831401 cites W2128016314 @default.
• W2065831401 cites W2128219894 @default.
• W2065831401 cites W2128989640 @default.
• W2065831401 cites W2132992030 @default.
• W2065831401 cites W2135197754 @default.
• W2065831401 cites W2138664009 @default.
• W2065831401 cites W2139871850 @default.
• W2065831401 cites W2144014661 @default.
• W2065831401 cites W2144896290 @default.
• W2065831401 cites W2146138309 @default.
• W2065831401 cites W2149146453 @default.
• W2065831401 cites W2149785901 @default.
• W2065831401 cites W2151922790 @default.
• W2065831401 cites W2153210075 @default.
• W2065831401 cites W2154688988 @default.
• W2065831401 cites W2155669068 @default.
• W2065831401 cites W2156491803 @default.
• W2065831401 cites W2159325140 @default.
• W2065831401 cites W2159793493 @default.
• W2065831401 cites W2160467221 @default.
• W2065831401 cites W2160913143 @default.
• W2065831401 cites W2163199119 @default.
• W2065831401 cites W2165674132 @default.
• W2065831401 cites W2167557255 @default.
• W2065831401 cites W2167566248 @default.
• W2065831401 cites W2169528473 @default.
• W2065831401 cites W2171707538 @default.
• W2065831401 cites W2918025614 @default.
• W2065831401 cites W4210430020 @default.
• W2065831401 cites W4229764382 @default.

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