FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065831736> ?p ?o ?g. }

• W2065831736 endingPage "1140" @default.
• W2065831736 startingPage "1133" @default.
• W2065831736 abstract "Shunaoxin pills, a traditional Chinese medicine (TCM) product, have been used to treat cerebrovascular diseases in China since 2005. The main active components of Shunaoxin pills are ferulic acid and ligustilide from Chuanxiong (Ligusticum chuanxiong Hort, Umbelliferae) and Danggui (Angelica sinensis radix, Umbelliferae). As Shunaoxin shows excellent activity in the central nervous system (CNS), the extent to which the major constituents of Shunaoxin reach the CNS should be investigated. Moreover, the in vivo–in vitro correlations (IVIVC) of the formulation should be studied to elucidate the mechanisms of action of TCM in the CNS. However, these data have not previously been available. Thus we intended to investigate what the extent when these constituents of Shunaoxin pills reach the CNS, and evaluate the IVIVC of release and pharmacokinetics. In this study, we evaluated the release of ferulic acid and ligustilide from Shunaoxin pills, and their transport across an in vitro model of the BBB. We also evaluated their pharmacokinetics and brain distribution in vivo. High-performance liquid chromatography (HPLC) was used to quantify both compounds simultaneously. Based on the release in vitro and absorption of ferulic acid and ligustilide in vivo, IVIVC permitted prediction of the pharmacokinetics of these compounds. The release of ferulic acid and ligustilide reached a platform phase within 1 h. Ferulic acid and ligustilide rapidly crossed the BBB in different patterns; the transport ratio increased over time. After intragastric (i.g.) administration of Shunaoxin pills, ferulic acid and ligustilide were rapidly absorbed and distributed into brain, which may result in a rapid onset of action. Ferulic acid and ligustilide were transported across a model BBB. After i.g. administration of Shunaoxin pills, ferulic acid and ligustilide were rapidly absorbed and distributed in brain; this may lead to rapid pharmacological onset. The IVIVC can be used to predict in vivo pharmacokinetics from in vitro experimental results. These results provide support for the clinical use of Shunaoxin pills." @default.
• W2065831736 created "2016-06-24" @default.
• W2065831736 creator A5005968050 @default.
• W2065831736 creator A5006012404 @default.
• W2065831736 creator A5032969232 @default.
• W2065831736 creator A5043373734 @default.
• W2065831736 date "2014-02-01" @default.
• W2065831736 modified "2023-10-18" @default.
• W2065831736 title "Pharmacokinetics, brain distribution, release and blood–brain barrier transport of Shunaoxin pills" @default.
• W2065831736 cites W1588854391 @default.
• W2065831736 cites W1965854886 @default.
• W2065831736 cites W1966451720 @default.
• W2065831736 cites W1967275315 @default.
• W2065831736 cites W1973485004 @default.
• W2065831736 cites W1974173278 @default.
• W2065831736 cites W1976726370 @default.
• W2065831736 cites W1984423213 @default.
• W2065831736 cites W1997890651 @default.
• W2065831736 cites W2000204972 @default.
• W2065831736 cites W2009918396 @default.
• W2065831736 cites W2013235824 @default.
• W2065831736 cites W2022704774 @default.
• W2065831736 cites W2022766782 @default.
• W2065831736 cites W2029105115 @default.
• W2065831736 cites W2030003382 @default.
• W2065831736 cites W2034459418 @default.
• W2065831736 cites W2042963739 @default.
• W2065831736 cites W2046381534 @default.
• W2065831736 cites W2057810771 @default.
• W2065831736 cites W2061673014 @default.
• W2065831736 cites W2064426437 @default.
• W2065831736 cites W2077770092 @default.
• W2065831736 cites W2080083185 @default.
• W2065831736 cites W2086079179 @default.
• W2065831736 cites W2113192813 @default.
• W2065831736 cites W2114918609 @default.
• W2065831736 cites W2129631130 @default.
• W2065831736 cites W2129733346 @default.
• W2065831736 cites W2132557995 @default.
• W2065831736 cites W2134195135 @default.
• W2065831736 cites W2135945275 @default.
• W2065831736 cites W2165950397 @default.
• W2065831736 cites W4327850830 @default.
• W2065831736 doi "https://doi.org/10.1016/j.jep.2013.12.027" @default.
• W2065831736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24373808" @default.
• W2065831736 hasPublicationYear "2014" @default.
• W2065831736 type Work @default.
• W2065831736 sameAs 2065831736 @default.
• W2065831736 citedByCount "31" @default.
• W2065831736 countsByYear W20658317362014 @default.
• W2065831736 countsByYear W20658317362015 @default.
• W2065831736 countsByYear W20658317362016 @default.
• W2065831736 countsByYear W20658317362017 @default.
• W2065831736 countsByYear W20658317362018 @default.
• W2065831736 countsByYear W20658317362019 @default.
• W2065831736 countsByYear W20658317362020 @default.
• W2065831736 countsByYear W20658317362021 @default.
• W2065831736 countsByYear W20658317362022 @default.
• W2065831736 countsByYear W20658317362023 @default.
• W2065831736 crossrefType "journal-article" @default.
• W2065831736 hasAuthorship W2065831736A5005968050 @default.
• W2065831736 hasAuthorship W2065831736A5006012404 @default.
• W2065831736 hasAuthorship W2065831736A5032969232 @default.
• W2065831736 hasAuthorship W2065831736A5043373734 @default.
• W2065831736 hasConcept C112705442 @default.
• W2065831736 hasConcept C14029885 @default.
• W2065831736 hasConcept C142724271 @default.
• W2065831736 hasConcept C150903083 @default.
• W2065831736 hasConcept C185592680 @default.
• W2065831736 hasConcept C188947578 @default.
• W2065831736 hasConcept C204787440 @default.
• W2065831736 hasConcept C207001950 @default.
• W2065831736 hasConcept C2779454681 @default.
• W2065831736 hasConcept C2779484521 @default.
• W2065831736 hasConcept C2780213334 @default.
• W2065831736 hasConcept C2781430271 @default.
• W2065831736 hasConcept C43617362 @default.
• W2065831736 hasConcept C71924100 @default.
• W2065831736 hasConcept C86803240 @default.
• W2065831736 hasConcept C98274493 @default.
• W2065831736 hasConceptScore W2065831736C112705442 @default.
• W2065831736 hasConceptScore W2065831736C14029885 @default.
• W2065831736 hasConceptScore W2065831736C142724271 @default.
• W2065831736 hasConceptScore W2065831736C150903083 @default.
• W2065831736 hasConceptScore W2065831736C185592680 @default.
• W2065831736 hasConceptScore W2065831736C188947578 @default.
• W2065831736 hasConceptScore W2065831736C204787440 @default.
• W2065831736 hasConceptScore W2065831736C207001950 @default.
• W2065831736 hasConceptScore W2065831736C2779454681 @default.
• W2065831736 hasConceptScore W2065831736C2779484521 @default.
• W2065831736 hasConceptScore W2065831736C2780213334 @default.
• W2065831736 hasConceptScore W2065831736C2781430271 @default.
• W2065831736 hasConceptScore W2065831736C43617362 @default.
• W2065831736 hasConceptScore W2065831736C71924100 @default.
• W2065831736 hasConceptScore W2065831736C86803240 @default.
• W2065831736 hasConceptScore W2065831736C98274493 @default.
• W2065831736 hasIssue "3" @default.
• W2065831736 hasLocation W20658317361 @default.

• next