Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065839303> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2065839303 endingPage "57" @default.
- W2065839303 startingPage "53" @default.
- W2065839303 abstract "Purpose: The aim of the work was to establish to what extent a variety of human severe-combined-immunodeficiency (SCID) disorders are associated with in vitro cellular hypersensitivity to ionizing radiation. Materials and methods: A study was made of fibroblast strains established from individuals with adenosine deaminase deficiency, T(−)B(−) SCID, Omenn's syndrome and a SCID heterozygote. For comparison, an assessment was also made of the radiosensitivity of a series of fibroblast strains derived from: normal donors, a patient with ataxia-telangiectasia (A-T) and an A-T heterozygote. Radiosensitivity was determined using a clonogenic assay following both high (HDR) and low (LDR) dose-rate irradiation. Results: Following HDR irradiation, the fibroblast strains derived from the different human SCID disorders displayed a wide range of radiosensitivity: the adenosine deaminase deficiency cells were similar in radiosensitivity to normal fibroblasts, T(−)B(−) cells were as hypersensitive to radiation as A-T cells and the Omenn's syndrome cells showed intermediate radiosensitivity. However, whereas all four normal cell strains studied showed significant LDR sparing, none of the SCID fibroblasts did. Conclusions: These data indicate that human SCID is variable in terms of radiosensitivity depending on the particular defect. In addition, the lack of LDR sparing of radiation-induced damage suggests the involvement of some form(s) of DNA repair defect in all the human SCID syndromes." @default.
- W2065839303 created "2016-06-24" @default.
- W2065839303 creator A5072603787 @default.
- W2065839303 creator A5079894409 @default.
- W2065839303 creator A5089539490 @default.
- W2065839303 date "1997-01-01" @default.
- W2065839303 modified "2023-10-02" @default.
- W2065839303 title "Cellular radiosensitivity in human severe-combined-immunodeficiency (SCID) syndromes" @default.
- W2065839303 cites W1550561387 @default.
- W2065839303 cites W1963675229 @default.
- W2065839303 cites W1970232857 @default.
- W2065839303 cites W1980715668 @default.
- W2065839303 cites W1989877475 @default.
- W2065839303 cites W2012192362 @default.
- W2065839303 cites W2016627831 @default.
- W2065839303 cites W2025247423 @default.
- W2065839303 cites W2050291003 @default.
- W2065839303 cites W2053040294 @default.
- W2065839303 cites W2076083889 @default.
- W2065839303 cites W2088843080 @default.
- W2065839303 cites W2117674648 @default.
- W2065839303 cites W2123733997 @default.
- W2065839303 cites W2139018276 @default.
- W2065839303 cites W2329987756 @default.
- W2065839303 doi "https://doi.org/10.1016/s0167-8140(96)01865-8" @default.
- W2065839303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9132827" @default.
- W2065839303 hasPublicationYear "1997" @default.
- W2065839303 type Work @default.
- W2065839303 sameAs 2065839303 @default.
- W2065839303 citedByCount "8" @default.
- W2065839303 countsByYear W20658393032019 @default.
- W2065839303 crossrefType "journal-article" @default.
- W2065839303 hasAuthorship W2065839303A5072603787 @default.
- W2065839303 hasAuthorship W2065839303A5079894409 @default.
- W2065839303 hasAuthorship W2065839303A5089539490 @default.
- W2065839303 hasConcept C117262875 @default.
- W2065839303 hasConcept C126322002 @default.
- W2065839303 hasConcept C143425029 @default.
- W2065839303 hasConcept C202751555 @default.
- W2065839303 hasConcept C203014093 @default.
- W2065839303 hasConcept C206684579 @default.
- W2065839303 hasConcept C207001950 @default.
- W2065839303 hasConcept C2776991684 @default.
- W2065839303 hasConcept C2777136964 @default.
- W2065839303 hasConcept C2779468541 @default.
- W2065839303 hasConcept C2779486608 @default.
- W2065839303 hasConcept C2780381497 @default.
- W2065839303 hasConcept C34628245 @default.
- W2065839303 hasConcept C502942594 @default.
- W2065839303 hasConcept C509974204 @default.
- W2065839303 hasConcept C54355233 @default.
- W2065839303 hasConcept C552990157 @default.
- W2065839303 hasConcept C71924100 @default.
- W2065839303 hasConcept C86803240 @default.
- W2065839303 hasConceptScore W2065839303C117262875 @default.
- W2065839303 hasConceptScore W2065839303C126322002 @default.
- W2065839303 hasConceptScore W2065839303C143425029 @default.
- W2065839303 hasConceptScore W2065839303C202751555 @default.
- W2065839303 hasConceptScore W2065839303C203014093 @default.
- W2065839303 hasConceptScore W2065839303C206684579 @default.
- W2065839303 hasConceptScore W2065839303C207001950 @default.
- W2065839303 hasConceptScore W2065839303C2776991684 @default.
- W2065839303 hasConceptScore W2065839303C2777136964 @default.
- W2065839303 hasConceptScore W2065839303C2779468541 @default.
- W2065839303 hasConceptScore W2065839303C2779486608 @default.
- W2065839303 hasConceptScore W2065839303C2780381497 @default.
- W2065839303 hasConceptScore W2065839303C34628245 @default.
- W2065839303 hasConceptScore W2065839303C502942594 @default.
- W2065839303 hasConceptScore W2065839303C509974204 @default.
- W2065839303 hasConceptScore W2065839303C54355233 @default.
- W2065839303 hasConceptScore W2065839303C552990157 @default.
- W2065839303 hasConceptScore W2065839303C71924100 @default.
- W2065839303 hasConceptScore W2065839303C86803240 @default.
- W2065839303 hasIssue "1" @default.
- W2065839303 hasLocation W20658393031 @default.
- W2065839303 hasLocation W20658393032 @default.
- W2065839303 hasOpenAccess W2065839303 @default.
- W2065839303 hasPrimaryLocation W20658393031 @default.
- W2065839303 hasRelatedWork W1582871837 @default.
- W2065839303 hasRelatedWork W1969496993 @default.
- W2065839303 hasRelatedWork W2016434246 @default.
- W2065839303 hasRelatedWork W2019460049 @default.
- W2065839303 hasRelatedWork W2041434120 @default.
- W2065839303 hasRelatedWork W2065839303 @default.
- W2065839303 hasRelatedWork W2071656187 @default.
- W2065839303 hasRelatedWork W2085485064 @default.
- W2065839303 hasRelatedWork W2401589187 @default.
- W2065839303 hasRelatedWork W3188938827 @default.
- W2065839303 hasVolume "42" @default.
- W2065839303 isParatext "false" @default.
- W2065839303 isRetracted "false" @default.
- W2065839303 magId "2065839303" @default.
- W2065839303 workType "article" @default.