FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065847595> ?p ?o ?g. }

• W2065847595 endingPage "10" @default.
• W2065847595 startingPage "1" @default.
• W2065847595 abstract "Control of pH in aminoethylation reactions is critical for maintaining high selectivity towards cysteine modification. Measurement of aminoethylation rate constants by liquid chromatography mass spectrometry demonstrates reaction selectivity of cysteine>>amino-terminus>>histidine. Lysine and methionine were not reactive at the conditions used. For thiol modification, the acid/base property of the gamma-thialysine residue measured by NMR results in a 1.15 decrease in pK(a) (relative to a lysine residue). NMR confirms ethylene imine is the reactive intermediate for alkylation of peptide nucleophiles with bromoethylamine. Conversion of bromoethylamine into ethylene imine prior to exposure to the target thiol, provides a reagent that promotes selectivity by allowing precise control of reaction pH. Reaction selectivity plots of relative aminoethylation rates for cysteine, histidine, and N-terminus imine demonstrate increasing alkaline conditions favors thiol modification. When applied to protein modification, the conversion of bromoethylamine into ethylene imine and buffering at alkaline pH will allow optimal cysteine residue aminoethylation." @default.
• W2065847595 created "2016-06-24" @default.
• W2065847595 creator A5006806888 @default.
• W2065847595 creator A5027073083 @default.
• W2065847595 creator A5049869511 @default.
• W2065847595 creator A5052725587 @default.
• W2065847595 date "2005-11-01" @default.
• W2065847595 modified "2023-10-12" @default.
• W2065847595 title "Aminoethylation in model peptides reveals conditions for maximizing thiol specificity" @default.
• W2065847595 cites W1516330854 @default.
• W2065847595 cites W1523552510 @default.
• W2065847595 cites W1587862303 @default.
• W2065847595 cites W1910292813 @default.
• W2065847595 cites W1964883087 @default.
• W2065847595 cites W1973251337 @default.
• W2065847595 cites W1980149636 @default.
• W2065847595 cites W2016366471 @default.
• W2065847595 cites W2032744348 @default.
• W2065847595 cites W2034634339 @default.
• W2065847595 cites W2043225353 @default.
• W2065847595 cites W2052509510 @default.
• W2065847595 cites W2052993818 @default.
• W2065847595 cites W2053035825 @default.
• W2065847595 cites W2054065615 @default.
• W2065847595 cites W2060116740 @default.
• W2065847595 cites W2065188339 @default.
• W2065847595 cites W2079043136 @default.
• W2065847595 cites W2082564323 @default.
• W2065847595 cites W2088786994 @default.
• W2065847595 cites W2091612484 @default.
• W2065847595 cites W2095761562 @default.
• W2065847595 cites W2158105833 @default.
• W2065847595 cites W2318448519 @default.
• W2065847595 cites W2328269693 @default.
• W2065847595 cites W2329980455 @default.
• W2065847595 cites W2471092558 @default.
• W2065847595 cites W2611550681 @default.
• W2065847595 doi "https://doi.org/10.1016/j.abb.2005.08.020" @default.
• W2065847595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16229814" @default.
• W2065847595 hasPublicationYear "2005" @default.
• W2065847595 type Work @default.
• W2065847595 sameAs 2065847595 @default.
• W2065847595 citedByCount "26" @default.
• W2065847595 countsByYear W20658475952012 @default.
• W2065847595 countsByYear W20658475952013 @default.
• W2065847595 countsByYear W20658475952014 @default.
• W2065847595 countsByYear W20658475952015 @default.
• W2065847595 countsByYear W20658475952016 @default.
• W2065847595 countsByYear W20658475952017 @default.
• W2065847595 countsByYear W20658475952018 @default.
• W2065847595 countsByYear W20658475952023 @default.
• W2065847595 crossrefType "journal-article" @default.
• W2065847595 hasAuthorship W2065847595A5006806888 @default.
• W2065847595 hasAuthorship W2065847595A5027073083 @default.
• W2065847595 hasAuthorship W2065847595A5049869511 @default.
• W2065847595 hasAuthorship W2065847595A5052725587 @default.
• W2065847595 hasConcept C118792377 @default.
• W2065847595 hasConcept C161790260 @default.
• W2065847595 hasConcept C164361826 @default.
• W2065847595 hasConcept C178790620 @default.
• W2065847595 hasConcept C178907741 @default.
• W2065847595 hasConcept C181199279 @default.
• W2065847595 hasConcept C185592680 @default.
• W2065847595 hasConcept C21951064 @default.
• W2065847595 hasConcept C2776016237 @default.
• W2065847595 hasConcept C2776573223 @default.
• W2065847595 hasConcept C2778460671 @default.
• W2065847595 hasConcept C2779201268 @default.
• W2065847595 hasConcept C2779281246 @default.
• W2065847595 hasConcept C2781324293 @default.
• W2065847595 hasConcept C2781338088 @default.
• W2065847595 hasConcept C40875361 @default.
• W2065847595 hasConcept C515207424 @default.
• W2065847595 hasConcept C55493867 @default.
• W2065847595 hasConceptScore W2065847595C118792377 @default.
• W2065847595 hasConceptScore W2065847595C161790260 @default.
• W2065847595 hasConceptScore W2065847595C164361826 @default.
• W2065847595 hasConceptScore W2065847595C178790620 @default.
• W2065847595 hasConceptScore W2065847595C178907741 @default.
• W2065847595 hasConceptScore W2065847595C181199279 @default.
• W2065847595 hasConceptScore W2065847595C185592680 @default.
• W2065847595 hasConceptScore W2065847595C21951064 @default.
• W2065847595 hasConceptScore W2065847595C2776016237 @default.
• W2065847595 hasConceptScore W2065847595C2776573223 @default.
• W2065847595 hasConceptScore W2065847595C2778460671 @default.
• W2065847595 hasConceptScore W2065847595C2779201268 @default.
• W2065847595 hasConceptScore W2065847595C2779281246 @default.
• W2065847595 hasConceptScore W2065847595C2781324293 @default.
• W2065847595 hasConceptScore W2065847595C2781338088 @default.
• W2065847595 hasConceptScore W2065847595C40875361 @default.
• W2065847595 hasConceptScore W2065847595C515207424 @default.
• W2065847595 hasConceptScore W2065847595C55493867 @default.
• W2065847595 hasIssue "1-2" @default.
• W2065847595 hasLocation W20658475951 @default.
• W2065847595 hasLocation W20658475952 @default.
• W2065847595 hasOpenAccess W2065847595 @default.
• W2065847595 hasPrimaryLocation W20658475951 @default.
• W2065847595 hasRelatedWork W1913270828 @default.

• next