FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065848008> ?p ?o ?g. }

• W2065848008 endingPage "347" @default.
• W2065848008 startingPage "347" @default.
• W2065848008 abstract "Sir, Plasmacytoma may be osseous (medullary) or nonosseous (extramedullary) and primary or secondary to disseminated multiple myeloma (MM). The skull base is one of the rarest sites of solitary plasmacytoma of the bone.[1] We present here a rare case of a patient with skull base plasmacytoma as the presenting sign of MM. A 58-year-old man with hypertension presented with a 3-month history of left-sided hearing loss, vertigo, and headache. On examination, there was left-sided sensory neural deafness. Laboratory tests showed normal hemogram, electrolytes, as well as renal and liver function. A possibility of cervical spondylosis was considered. Head and cervical spine magnetic resonance imaging [Figure 1] revealed destruction of the clivus that was replaced by a moderately enhancing mass lesion, which was hypointense on unenhanced T1-weighted images and iso- to hypointense on T2-weighted images. Laterally, the lesion infiltrated both petrous apices, mostly on the left side, infiltrating the left jugular bulb and extending posterolaterally up to the left sigmoid sinus in the left cerebellopontine angle cistern. Computed tomography of Head [Figure 2] showed an osteolytic lesion with areas of spotty calcification. Skeletal radiological work-up was normal. A transnasal biopsy of the lesion showed plasmacytoma of the bone [Figure 3]. b2-Microglobulin was 2373.0 ng/mL and serum protein electrophoresis did not reveal M-band. Urine was negative for Bence Jones proteins. Peripheral smear was normal. A bone marrow aspiration study showed 41% of atypical plasma cells, binucleate forms, and plasma blast, suggestive for MM. The patient was treated with 6 cycles of high dose dexamethasone (40 mg/d intravenously for 4 d/cycle) and thalidomide (200 mg/d orally for 28 d/cycle), and local irradiation (40 Gy 20 fractions over 4 wk). After completion of this treatment, he has been referred for bone marrow transplantation.Figure 1: Head and cervical spine magnetic resonance imagingFigure 2: Computed tomography scan of the patient's headFigure 3: Bone marrow aspirate stained with Giemsa stain (magnification, x600)Plasma cell neoplasm included MM, monoclonal gammapathies of unknown significance, plasmacytomas, and plasma cell leukemia.[2] MM is the most common type of plasma cell neoplasm. Plasmacytoma represents a local form of plasma cell neoplasm.[3] Plasmacytomas represent less than 1% of all head and neck tumors.[4] Primary extramedullary plasmacytomas represent less than 4% of all plasma cell tumors, most often involving the upper aerodigestive tracts and paranasal sinuses.[45] Solitary intracranial plasmacytoma is exceedingly rare,[6] and may arise from the skull, leptomeninges, or the brain. When the skull is involved, most of the plasmacytomas occur in the calvarium and the skull base is rarely affected. Here, they may occur in the clivus, such as in the case presented herein, or in the petrous apex. In conclusion, this is a rare clinical presentation since the patient did not have any other features of MM and it highlights the importance of extensive evaluation of patients with atypical neurological symptoms." @default.
• W2065848008 created "2016-06-24" @default.
• W2065848008 creator A5036843108 @default.
• W2065848008 creator A5044720787 @default.
• W2065848008 creator A5054565340 @default.
• W2065848008 creator A5071974745 @default.
• W2065848008 date "2010-01-01" @default.
• W2065848008 modified "2023-10-03" @default.
• W2065848008 title "Unusual presentation of multiple myeloma" @default.
• W2065848008 doi "https://doi.org/10.4103/0019-509x.64709" @default.
• W2065848008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20587918" @default.
• W2065848008 hasPublicationYear "2010" @default.
• W2065848008 type Work @default.
• W2065848008 sameAs 2065848008 @default.
• W2065848008 citedByCount "2" @default.
• W2065848008 countsByYear W20658480082017 @default.
• W2065848008 countsByYear W20658480082018 @default.
• W2065848008 crossrefType "journal-article" @default.
• W2065848008 hasAuthorship W2065848008A5036843108 @default.
• W2065848008 hasAuthorship W2065848008A5044720787 @default.
• W2065848008 hasAuthorship W2065848008A5054565340 @default.
• W2065848008 hasAuthorship W2065848008A5071974745 @default.
• W2065848008 hasConcept C105702510 @default.
• W2065848008 hasConcept C126838900 @default.
• W2065848008 hasConcept C142724271 @default.
• W2065848008 hasConcept C157369684 @default.
• W2065848008 hasConcept C203014093 @default.
• W2065848008 hasConcept C2776289866 @default.
• W2065848008 hasConcept C2776364478 @default.
• W2065848008 hasConcept C2776407911 @default.
• W2065848008 hasConcept C2778964538 @default.
• W2065848008 hasConcept C2779300802 @default.
• W2065848008 hasConcept C2779782008 @default.
• W2065848008 hasConcept C59822182 @default.
• W2065848008 hasConcept C71924100 @default.
• W2065848008 hasConcept C86803240 @default.
• W2065848008 hasConceptScore W2065848008C105702510 @default.
• W2065848008 hasConceptScore W2065848008C126838900 @default.
• W2065848008 hasConceptScore W2065848008C142724271 @default.
• W2065848008 hasConceptScore W2065848008C157369684 @default.
• W2065848008 hasConceptScore W2065848008C203014093 @default.
• W2065848008 hasConceptScore W2065848008C2776289866 @default.
• W2065848008 hasConceptScore W2065848008C2776364478 @default.
• W2065848008 hasConceptScore W2065848008C2776407911 @default.
• W2065848008 hasConceptScore W2065848008C2778964538 @default.
• W2065848008 hasConceptScore W2065848008C2779300802 @default.
• W2065848008 hasConceptScore W2065848008C2779782008 @default.
• W2065848008 hasConceptScore W2065848008C59822182 @default.
• W2065848008 hasConceptScore W2065848008C71924100 @default.
• W2065848008 hasConceptScore W2065848008C86803240 @default.
• W2065848008 hasIssue "3" @default.
• W2065848008 hasLocation W20658480081 @default.
• W2065848008 hasLocation W20658480082 @default.
• W2065848008 hasOpenAccess W2065848008 @default.
• W2065848008 hasPrimaryLocation W20658480081 @default.
• W2065848008 hasRelatedWork W181801700 @default.
• W2065848008 hasRelatedWork W1966145063 @default.
• W2065848008 hasRelatedWork W1971360305 @default.
• W2065848008 hasRelatedWork W1991415405 @default.
• W2065848008 hasRelatedWork W2042099714 @default.
• W2065848008 hasRelatedWork W2156455014 @default.
• W2065848008 hasRelatedWork W2172522149 @default.
• W2065848008 hasRelatedWork W2517870438 @default.
• W2065848008 hasRelatedWork W3174750179 @default.
• W2065848008 hasRelatedWork W4283738933 @default.
• W2065848008 hasVolume "47" @default.
• W2065848008 isParatext "false" @default.
• W2065848008 isRetracted "false" @default.
• W2065848008 magId "2065848008" @default.
• W2065848008 workType "article" @default.