Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065852913> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2065852913 endingPage "122" @default.
- W2065852913 startingPage "113" @default.
- W2065852913 abstract "To understand mechanism underlying the age-related impairment of T cell functions, changes in the expression of cell surface receptors were examined in T cells after mitogenic stimulation by flow cytometry and results were compared between young and old mice. Before stimulation, no significant difference was observed in the density of TCRαβ, CD3, CD122 (IL-2Rβ), IL-2Rγ, CD28 and CD95 (Fas) of T cells between young and old mice. As for CD25(IL-2Rα) and CTLA-4, relative intensity and percentage of positive cells were higher in old than in young mice, although the levels were low compared with those after stimulation. After mitogenic stimulation, increased expression of the density was observed in CD25, IL-2Rβ, IL-2Rγ, CD28, CTLA-4 and CD95 and the magnitude of increase was more pronounced in T cells from young than those from old mice. The expression of TCRαβ and CD3 decreased after mitogenic stimulation, and the degree of expression quickly recovered to the initial level in young mice, but not in old mice. Lower expression of TCR, IL-2 receptors and co-stimulatory molecules in T cells from old mice could be responsible for the impaired proliferation after mitogenic stimulation." @default.
- W2065852913 created "2016-06-24" @default.
- W2065852913 creator A5028587082 @default.
- W2065852913 creator A5068651868 @default.
- W2065852913 creator A5074754504 @default.
- W2065852913 date "1997-03-01" @default.
- W2065852913 modified "2023-10-18" @default.
- W2065852913 title "Altered expression of various receptors on T cells in young and old mice after mitogenic stimulation: a flow cytometric analysis" @default.
- W2065852913 cites W167981432 @default.
- W2065852913 cites W1971332992 @default.
- W2065852913 cites W1994187261 @default.
- W2065852913 cites W1994706890 @default.
- W2065852913 cites W1999764514 @default.
- W2065852913 cites W2000423367 @default.
- W2065852913 cites W2003612217 @default.
- W2065852913 cites W2015085911 @default.
- W2065852913 cites W2017799223 @default.
- W2065852913 cites W2063023419 @default.
- W2065852913 cites W2089694773 @default.
- W2065852913 cites W2092643850 @default.
- W2065852913 cites W2109367436 @default.
- W2065852913 cites W2110062670 @default.
- W2065852913 cites W2133811759 @default.
- W2065852913 doi "https://doi.org/10.1016/s0047-6374(97)01880-0" @default.
- W2065852913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9147364" @default.
- W2065852913 hasPublicationYear "1997" @default.
- W2065852913 type Work @default.
- W2065852913 sameAs 2065852913 @default.
- W2065852913 citedByCount "55" @default.
- W2065852913 countsByYear W20658529132012 @default.
- W2065852913 countsByYear W20658529132014 @default.
- W2065852913 countsByYear W20658529132016 @default.
- W2065852913 countsByYear W20658529132018 @default.
- W2065852913 countsByYear W20658529132019 @default.
- W2065852913 countsByYear W20658529132021 @default.
- W2065852913 crossrefType "journal-article" @default.
- W2065852913 hasAuthorship W2065852913A5028587082 @default.
- W2065852913 hasAuthorship W2065852913A5068651868 @default.
- W2065852913 hasAuthorship W2065852913A5074754504 @default.
- W2065852913 hasConcept C114684123 @default.
- W2065852913 hasConcept C126322002 @default.
- W2065852913 hasConcept C134018914 @default.
- W2065852913 hasConcept C148125776 @default.
- W2065852913 hasConcept C153911025 @default.
- W2065852913 hasConcept C167672396 @default.
- W2065852913 hasConcept C170493617 @default.
- W2065852913 hasConcept C19317047 @default.
- W2065852913 hasConcept C203014093 @default.
- W2065852913 hasConcept C24998067 @default.
- W2065852913 hasConcept C2776090121 @default.
- W2065852913 hasConcept C2777371288 @default.
- W2065852913 hasConcept C2992881475 @default.
- W2065852913 hasConcept C553184892 @default.
- W2065852913 hasConcept C71924100 @default.
- W2065852913 hasConcept C79484868 @default.
- W2065852913 hasConcept C86803240 @default.
- W2065852913 hasConcept C8891405 @default.
- W2065852913 hasConceptScore W2065852913C114684123 @default.
- W2065852913 hasConceptScore W2065852913C126322002 @default.
- W2065852913 hasConceptScore W2065852913C134018914 @default.
- W2065852913 hasConceptScore W2065852913C148125776 @default.
- W2065852913 hasConceptScore W2065852913C153911025 @default.
- W2065852913 hasConceptScore W2065852913C167672396 @default.
- W2065852913 hasConceptScore W2065852913C170493617 @default.
- W2065852913 hasConceptScore W2065852913C19317047 @default.
- W2065852913 hasConceptScore W2065852913C203014093 @default.
- W2065852913 hasConceptScore W2065852913C24998067 @default.
- W2065852913 hasConceptScore W2065852913C2776090121 @default.
- W2065852913 hasConceptScore W2065852913C2777371288 @default.
- W2065852913 hasConceptScore W2065852913C2992881475 @default.
- W2065852913 hasConceptScore W2065852913C553184892 @default.
- W2065852913 hasConceptScore W2065852913C71924100 @default.
- W2065852913 hasConceptScore W2065852913C79484868 @default.
- W2065852913 hasConceptScore W2065852913C86803240 @default.
- W2065852913 hasConceptScore W2065852913C8891405 @default.
- W2065852913 hasIssue "1-3" @default.
- W2065852913 hasLocation W20658529131 @default.
- W2065852913 hasLocation W20658529132 @default.
- W2065852913 hasOpenAccess W2065852913 @default.
- W2065852913 hasPrimaryLocation W20658529131 @default.
- W2065852913 hasRelatedWork W1542374316 @default.
- W2065852913 hasRelatedWork W1602975132 @default.
- W2065852913 hasRelatedWork W1967977709 @default.
- W2065852913 hasRelatedWork W1970199044 @default.
- W2065852913 hasRelatedWork W1974955853 @default.
- W2065852913 hasRelatedWork W2025159433 @default.
- W2065852913 hasRelatedWork W2025730147 @default.
- W2065852913 hasRelatedWork W2131648606 @default.
- W2065852913 hasRelatedWork W2148489435 @default.
- W2065852913 hasRelatedWork W2354718978 @default.
- W2065852913 hasVolume "94" @default.
- W2065852913 isParatext "false" @default.
- W2065852913 isRetracted "false" @default.
- W2065852913 magId "2065852913" @default.
- W2065852913 workType "article" @default.