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- W2065852918 abstract "Multispectral automated segmentation of MR images of the brains of 10 young (5–8 years), 10 middle-aged (12–17 years), and 11 old (21–27 years) female rhesus monkeys revealed age-associated changes in brain volume and composition. Total brain parenchymal volume (expressed as fraction of intracranial volume—%ICV) decreased at a linear rate of 0.3±0.04% ICV/year. Up to age ∼15 years, this loss was almost entirely due to gray matter loss, with a compensatory increase in cerebrospinal fluid (CSF), and possibly some white matter. Brain tissue composition, expressed as the gray matter/white matter volume ratio confirmed that gray matter loss exceeded white matter loss, but the rate of decline in the gray/white ratio began to slow after ∼15 years. Comparison of these age-associated changes in rhesus brain with those in humans suggest that the brain aging in rhesus is a good model of human brain aging, but occurs ∼3-fold faster." @default.
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- W2065852918 date "1999-05-01" @default.
- W2065852918 modified "2023-10-18" @default.
- W2065852918 title "Age-associated changes in rhesus CNS composition identified by MRI" @default.
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- W2065852918 doi "https://doi.org/10.1016/s0006-8993(99)01343-8" @default.
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