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- W2065853596 abstract "Activator and inhibitor roles for the 88-kDa-secreted glycoprotein progranulin (PGRN) have been demonstrated in ovarian cancer cells. Here, we investigated the effects of PGRN in breast cancer migration. Testing MCF7, MDA-MB-453, and MDA-MB-231 human breast cancer cells and the MCF10A breast epithelial cell line, we demonstrate that LPA-induced PGRN stimulation led to a significant increase in cell invasion of MDA-MB-453 and MDA-MB-231 cells only (p < 0.05). Moreover, incubation with an anti-PGRN antibody, an inhibitor of the ERK pathway (PD98059) or both in combination inhibited the ability of MDA-MB-231 cells to invade. Furthermore, the expression of focal adhesion kinases promoted by LPA-induced PGRN was also inhibited by PD98059 alone or in combination with an anti-PGRN antibody (p < 0.05). Taken together, these results suggest that the LPA activation of PGRN involving the ERK pathway is critical to promote MDA-MB-231 breast cancer cell invasion." @default.
- W2065853596 created "2016-06-24" @default.
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- W2065853596 date "2011-12-01" @default.
- W2065853596 modified "2023-09-30" @default.
- W2065853596 title "Progranulin Stimulated by LPA Promotes the Migration of Aggressive Breast Cancer Cells" @default.
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- W2065853596 doi "https://doi.org/10.3109/15419061.2011.641042" @default.
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