FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065853910> ?p ?o ?g. }

• W2065853910 endingPage "56" @default.
• W2065853910 startingPage "49" @default.
• W2065853910 abstract "Aspirin (acetylsalicylic acid) is a well-known and widely-used analgesic. It is rapidly deacetylated to salicylic acid, which forms two hippuric acids—salicyluric acid and gentisuric acid—and two glucuronides. The oxidation of aspirin and salicylic acid has been reported with human liver microsomes, but data on individual cytochromes P450 involved in oxidation is lacking. In this study we monitored oxidation of these compounds by human liver microsomes and cytochrome P450 (P450) using UPLC with fluorescence detection. Microsomal oxidation of salicylic acid was much faster than aspirin. The two oxidation products were 2,5-dihydroxybenzoic acid (gentisic acid, documented by its UV and mass spectrum) and 2,3-dihydroxybenzoic acid. Formation of neither product was inhibited by desferrioxamine, suggesting a lack of contribution of oxygen radicals under these conditions. Although more liphophilic, aspirin was oxidized less efficiently, primarily to the 2,5-dihydroxy product. Recombinant human P450s 2C8, 2C9, 2C19, 2D6, 2E1, and 3A4 all catalyzed the 5-hydroxylation of salicylic acid. Inhibitor studies with human liver microsomes indicated that all six of the previously mentioned P450s could contribute to both the 5- and 3-hydroxylation of salicylic acid and that P450s 2A6 and 2B6 have contributions to 5-hydroxylation. Inhibitor studies indicated that the major human P450 involved in both 3- and 5-hydroxylation of salicylic acid is P450 2E1." @default.
• W2065853910 created "2016-06-24" @default.
• W2065853910 creator A5004306171 @default.
• W2065853910 creator A5055603347 @default.
• W2065853910 creator A5056982214 @default.
• W2065853910 creator A5058389506 @default.
• W2065853910 date "2015-06-01" @default.
• W2065853910 modified "2023-09-26" @default.
• W2065853910 title "Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450" @default.
• W2065853910 cites W1563004338 @default.
• W2065853910 cites W1583125800 @default.
• W2065853910 cites W1592783225 @default.
• W2065853910 cites W1802772100 @default.
• W2065853910 cites W1825467595 @default.
• W2065853910 cites W1847256235 @default.
• W2065853910 cites W1963877143 @default.
• W2065853910 cites W1967220665 @default.
• W2065853910 cites W1987053951 @default.
• W2065853910 cites W1991231974 @default.
• W2065853910 cites W1991232824 @default.
• W2065853910 cites W1993763734 @default.
• W2065853910 cites W2013182327 @default.
• W2065853910 cites W2014362986 @default.
• W2065853910 cites W2029810822 @default.
• W2065853910 cites W2041258806 @default.
• W2065853910 cites W2043842514 @default.
• W2065853910 cites W2048746773 @default.
• W2065853910 cites W2056820816 @default.
• W2065853910 cites W2074151184 @default.
• W2065853910 cites W2074480733 @default.
• W2065853910 cites W2076943035 @default.
• W2065853910 cites W2077370068 @default.
• W2065853910 cites W2081803698 @default.
• W2065853910 cites W2085717234 @default.
• W2065853910 cites W2091094310 @default.
• W2065853910 cites W2094867651 @default.
• W2065853910 cites W2102115790 @default.
• W2065853910 cites W2116118927 @default.
• W2065853910 cites W2118188075 @default.
• W2065853910 cites W2136162777 @default.
• W2065853910 cites W2141119205 @default.
• W2065853910 cites W2154291996 @default.
• W2065853910 cites W2416782574 @default.
• W2065853910 cites W4229819728 @default.
• W2065853910 doi "https://doi.org/10.1016/j.ejps.2015.03.015" @default.
• W2065853910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4414920" @default.
• W2065853910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25840124" @default.
• W2065853910 hasPublicationYear "2015" @default.
• W2065853910 type Work @default.
• W2065853910 sameAs 2065853910 @default.
• W2065853910 citedByCount "32" @default.
• W2065853910 countsByYear W20658539102017 @default.
• W2065853910 countsByYear W20658539102018 @default.
• W2065853910 countsByYear W20658539102019 @default.
• W2065853910 countsByYear W20658539102020 @default.
• W2065853910 countsByYear W20658539102021 @default.
• W2065853910 countsByYear W20658539102022 @default.
• W2065853910 countsByYear W20658539102023 @default.
• W2065853910 crossrefType "journal-article" @default.
• W2065853910 hasAuthorship W2065853910A5004306171 @default.
• W2065853910 hasAuthorship W2065853910A5055603347 @default.
• W2065853910 hasAuthorship W2065853910A5056982214 @default.
• W2065853910 hasAuthorship W2065853910A5058389506 @default.
• W2065853910 hasBestOaLocation W20658539102 @default.
• W2065853910 hasConcept C181199279 @default.
• W2065853910 hasConcept C185592680 @default.
• W2065853910 hasConcept C2777628954 @default.
• W2065853910 hasConcept C2778221352 @default.
• W2065853910 hasConcept C2778236623 @default.
• W2065853910 hasConcept C2781109383 @default.
• W2065853910 hasConcept C526171541 @default.
• W2065853910 hasConcept C55493867 @default.
• W2065853910 hasConcept C62231903 @default.
• W2065853910 hasConcept C87644729 @default.
• W2065853910 hasConceptScore W2065853910C181199279 @default.
• W2065853910 hasConceptScore W2065853910C185592680 @default.
• W2065853910 hasConceptScore W2065853910C2777628954 @default.
• W2065853910 hasConceptScore W2065853910C2778221352 @default.
• W2065853910 hasConceptScore W2065853910C2778236623 @default.
• W2065853910 hasConceptScore W2065853910C2781109383 @default.
• W2065853910 hasConceptScore W2065853910C526171541 @default.
• W2065853910 hasConceptScore W2065853910C55493867 @default.
• W2065853910 hasConceptScore W2065853910C62231903 @default.
• W2065853910 hasConceptScore W2065853910C87644729 @default.
• W2065853910 hasLocation W20658539101 @default.
• W2065853910 hasLocation W20658539102 @default.
• W2065853910 hasLocation W20658539103 @default.
• W2065853910 hasLocation W20658539104 @default.
• W2065853910 hasOpenAccess W2065853910 @default.
• W2065853910 hasPrimaryLocation W20658539101 @default.
• W2065853910 hasRelatedWork W2008928354 @default.
• W2065853910 hasRelatedWork W2059640317 @default.
• W2065853910 hasRelatedWork W2064285428 @default.
• W2065853910 hasRelatedWork W2065853910 @default.
• W2065853910 hasRelatedWork W2069734079 @default.
• W2065853910 hasRelatedWork W2082236245 @default.
• W2065853910 hasRelatedWork W2118876857 @default.
• W2065853910 hasRelatedWork W2145895498 @default.

• next