Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065856656> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2065856656 endingPage "100" @default.
- W2065856656 startingPage "97" @default.
- W2065856656 abstract "It has been reported earlier that rat microvessels which constitute the blood-brain barrier (BBB) are rich in free radical scavenging enzymes. In the present investigation, BBB of rat was disrupted by intravenous infusion of the hypertonic saline and changes in enzymes--namely, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR)--were evaluated in the brain microvessels at 30 min after the intravenous administration of hypertonic saline, being the time of peak effect. There was a significant increase in the activities of CAT (40%), GPx (26%), and SOD (16%) over the control values. In addition, within 90 min BBB was found to be reestablished and the levels of enzymes reverted to normal. Malondialdehyde (MDA) levels and activity of lactate dehydrogenase (LDH) remained unaltered during and following disruption, suggesting that there was no change in the membrane lipid environment. Similarly, there was no cell lysis. The results suggest that the disruption of BBB following hypertonic saline administration might be due to an increase in the generation of free radicals in the brain microvessels." @default.
- W2065856656 created "2016-06-24" @default.
- W2065856656 creator A5026900397 @default.
- W2065856656 creator A5060700887 @default.
- W2065856656 creator A5060712880 @default.
- W2065856656 creator A5080839240 @default.
- W2065856656 date "1993-07-01" @default.
- W2065856656 modified "2023-09-25" @default.
- W2065856656 title "Alterations in free radical scavenging mechanisms following blood-brain barrier disruption" @default.
- W2065856656 cites W185892090 @default.
- W2065856656 cites W1966861130 @default.
- W2065856656 cites W1983310681 @default.
- W2065856656 cites W1987093267 @default.
- W2065856656 cites W2013881893 @default.
- W2065856656 cites W2022054438 @default.
- W2065856656 cites W2038729523 @default.
- W2065856656 cites W2040429969 @default.
- W2065856656 cites W2066876892 @default.
- W2065856656 cites W2073738453 @default.
- W2065856656 cites W2087035038 @default.
- W2065856656 cites W2144924489 @default.
- W2065856656 doi "https://doi.org/10.1016/0891-5849(93)90128-h" @default.
- W2065856656 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8359713" @default.
- W2065856656 hasPublicationYear "1993" @default.
- W2065856656 type Work @default.
- W2065856656 sameAs 2065856656 @default.
- W2065856656 citedByCount "23" @default.
- W2065856656 countsByYear W20658566562013 @default.
- W2065856656 countsByYear W20658566562014 @default.
- W2065856656 crossrefType "journal-article" @default.
- W2065856656 hasAuthorship W2065856656A5026900397 @default.
- W2065856656 hasAuthorship W2065856656A5060700887 @default.
- W2065856656 hasAuthorship W2065856656A5060712880 @default.
- W2065856656 hasAuthorship W2065856656A5080839240 @default.
- W2065856656 hasConcept C117277713 @default.
- W2065856656 hasConcept C126322002 @default.
- W2065856656 hasConcept C134018914 @default.
- W2065856656 hasConcept C165069038 @default.
- W2065856656 hasConcept C181199279 @default.
- W2065856656 hasConcept C185592680 @default.
- W2065856656 hasConcept C2775838275 @default.
- W2065856656 hasConcept C2777318727 @default.
- W2065856656 hasConcept C2778004101 @default.
- W2065856656 hasConcept C2778401633 @default.
- W2065856656 hasConcept C2778402981 @default.
- W2065856656 hasConcept C2778760513 @default.
- W2065856656 hasConcept C2778979269 @default.
- W2065856656 hasConcept C3017567848 @default.
- W2065856656 hasConcept C529278444 @default.
- W2065856656 hasConcept C538909803 @default.
- W2065856656 hasConcept C55493867 @default.
- W2065856656 hasConcept C71924100 @default.
- W2065856656 hasConcept C86803240 @default.
- W2065856656 hasConcept C98274493 @default.
- W2065856656 hasConceptScore W2065856656C117277713 @default.
- W2065856656 hasConceptScore W2065856656C126322002 @default.
- W2065856656 hasConceptScore W2065856656C134018914 @default.
- W2065856656 hasConceptScore W2065856656C165069038 @default.
- W2065856656 hasConceptScore W2065856656C181199279 @default.
- W2065856656 hasConceptScore W2065856656C185592680 @default.
- W2065856656 hasConceptScore W2065856656C2775838275 @default.
- W2065856656 hasConceptScore W2065856656C2777318727 @default.
- W2065856656 hasConceptScore W2065856656C2778004101 @default.
- W2065856656 hasConceptScore W2065856656C2778401633 @default.
- W2065856656 hasConceptScore W2065856656C2778402981 @default.
- W2065856656 hasConceptScore W2065856656C2778760513 @default.
- W2065856656 hasConceptScore W2065856656C2778979269 @default.
- W2065856656 hasConceptScore W2065856656C3017567848 @default.
- W2065856656 hasConceptScore W2065856656C529278444 @default.
- W2065856656 hasConceptScore W2065856656C538909803 @default.
- W2065856656 hasConceptScore W2065856656C55493867 @default.
- W2065856656 hasConceptScore W2065856656C71924100 @default.
- W2065856656 hasConceptScore W2065856656C86803240 @default.
- W2065856656 hasConceptScore W2065856656C98274493 @default.
- W2065856656 hasIssue "1" @default.
- W2065856656 hasLocation W20658566561 @default.
- W2065856656 hasLocation W20658566562 @default.
- W2065856656 hasOpenAccess W2065856656 @default.
- W2065856656 hasPrimaryLocation W20658566561 @default.
- W2065856656 hasRelatedWork W159419932 @default.
- W2065856656 hasRelatedWork W1969555927 @default.
- W2065856656 hasRelatedWork W2037078933 @default.
- W2065856656 hasRelatedWork W2090665895 @default.
- W2065856656 hasRelatedWork W2090886218 @default.
- W2065856656 hasRelatedWork W2366512344 @default.
- W2065856656 hasRelatedWork W2411875264 @default.
- W2065856656 hasRelatedWork W2726026000 @default.
- W2065856656 hasRelatedWork W2891721693 @default.
- W2065856656 hasRelatedWork W3200659209 @default.
- W2065856656 hasVolume "15" @default.
- W2065856656 isParatext "false" @default.
- W2065856656 isRetracted "false" @default.
- W2065856656 magId "2065856656" @default.
- W2065856656 workType "article" @default.