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• W2065856887 endingPage "e53949" @default.
• W2065856887 startingPage "e53949" @default.
• W2065856887 abstract "The worldwide occurrence of cyanobacterial blooms evokes profound concerns. The presence of microcystins (MCs) in waters and aquatic food increases the risk to human health. Some recent studies have suggested that the gonad is the second most important target organ of MCs, however, the potential toxicity mechanisms are still unclear. For a better understanding of reproductive toxicity of MCs on animals, we conducted the present experimental investigation. Male rats were intraperitoneally injected with MC-LR for 50 d with the doses of 1 and 10 µg/kg body weight per day. After prolonged exposure to MC-LR, the testes index significantly decreased in 10 µg/kg group. Light microscope observation indicated that the space between the seminiferous tubules was increased. Ultrastructural observation showed some histopathological characteristics, including cytoplasmic shrinkage, cell membrane blebbing, swollen mitochondria and deformed nucleus. Using Q-PCR methods, the transcriptional levels of some cytoskeletal and mitochondrial genes were determined. MC-LR exposure affected the homeostasis of the expression of cytoskeletal genes, causing possible dysfunction of cytoskeleton assembly. In MC-LR treatments, all the 8 mitochondrial genes related with oxidative phosphorylation (OXPHOS) significantly increased. The reactive oxygen species (ROS) level significantly increased in 10 µg/kg group. The mitochondria swelling and DNA damage were also determined in 10 µg/kg group. Hormone levels of testis significantly changed. The present study verified that both cytoskeleton disruption possibly due to cytoskeletal reorganization or depolymerization and mitochondria dysfunction interact with each other through inducing of reactive oxygen species and oxidative phosphorylation, and jointly result in testis impairment after exposure to MC-LR." @default.
• W2065856887 created "2016-06-24" @default.
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• W2065856887 date "2013-01-16" @default.
• W2065856887 modified "2023-10-15" @default.
• W2065856887 title "The Interactive Effects of Cytoskeleton Disruption and Mitochondria Dysfunction Lead to Reproductive Toxicity Induced by Microcystin-LR" @default.
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• W2065856887 cites W1967388408 @default.
• W2065856887 cites W1968015182 @default.
• W2065856887 cites W1968534841 @default.
• W2065856887 cites W1970473512 @default.
• W2065856887 cites W1970863012 @default.
• W2065856887 cites W1971536244 @default.
• W2065856887 cites W1973210866 @default.
• W2065856887 cites W1977139014 @default.
• W2065856887 cites W1977532369 @default.
• W2065856887 cites W1977712275 @default.
• W2065856887 cites W1986057222 @default.
• W2065856887 cites W1986244191 @default.
• W2065856887 cites W1988228934 @default.
• W2065856887 cites W1989514272 @default.
• W2065856887 cites W1992204824 @default.
• W2065856887 cites W1994260666 @default.
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• W2065856887 cites W2008878988 @default.
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• W2065856887 cites W2032450650 @default.
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• W2065856887 cites W2038372048 @default.
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• W2065856887 cites W2042603980 @default.
• W2065856887 cites W2045509536 @default.
• W2065856887 cites W2053167022 @default.
• W2065856887 cites W2056074767 @default.
• W2065856887 cites W2057796711 @default.
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• W2065856887 doi "https://doi.org/10.1371/journal.pone.0053949" @default.
• W2065856887 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3547071" @default.
• W2065856887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23342045" @default.
• W2065856887 hasPublicationYear "2013" @default.
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