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- W2065863360 abstract "Defects of growth inhibitory pathways have an important role in disorders of cell growth and differentiation. The discovery of a mutation in one of the principle components of the transforming growth factor β (TGFβ) receptor system which is linked to a DNA repair defect(1) represents one possible mechanism of escape from negative regulatory influences acting upon cells. TGFβ is a pre-eminent negative growth factor and this article discusses (1) the role of TGFβ in maintaining epithelial homeostasis; (2) how breakdown of inhibitory pathways can promote neoplastic development; (3) the significance of a receptor defect in a negative signalling pathway; and (4) the potential therapeutic sequelae resulting from restoration of cellular responsiveness to TGFβ." @default.
- W2065863360 created "2016-06-24" @default.
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- W2065863360 date "1995-12-01" @default.
- W2065863360 modified "2023-09-26" @default.
- W2065863360 title "Microsatellite instability and a TGF? receptor: Clues to A growth control pathway" @default.
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- W2065863360 doi "https://doi.org/10.1002/bies.950171203" @default.
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