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- W2065863754 abstract "Abstract The effect of natural ACTH and synthetic β 1–24 - and β 1–18 -corticotrophins on the extra-adrenal metabolism of cortisol and aldosterone was studied in patients with Addison's disease. ACTH enlarged the distribution volume of the steroids and slowed down their rate of disappearance from the plasma. In the case of cortisol. ACTH augmented its urinary excretion and percentage conversion into unconjugated 4-ene-3-oxometabolites, and diminished the conversion into metabolites with an oxogroup at C-11 and 11-oxygenated 17-oxosteroids. These effects were observed in a wide range of administered doses of cortisol (20–400 mg daily) and persisted after prolonged administration of ACTH for three to six weeks. At this time, a distinct reduction of the transcortin binding capacity for cortisol occurred in two out of three experiments. The results suggest that ACTH enhances cellular uptake of cortisol and aldosterone, and inhibits the reduction of ring A of the steroid molecule. In the case of cortisol, ACTH inhibits to some extent also the 11β-OH dehydrogenation and the cleavage of the side chain, and possibly reduces the binding capacity of transcortin." @default.
- W2065863754 created "2016-06-24" @default.
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- W2065863754 date "1975-02-01" @default.
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- W2065863754 title "Effect of natural and synthetic β1–24- and β1–18-corticotrophins on the extra-adrenal metabolism of cortisol and aldosterone in patients with addison's disease" @default.
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- W2065863754 doi "https://doi.org/10.1016/0022-4731(75)90194-6" @default.
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