Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065864578> ?p ?o ?g. }
- W2065864578 endingPage "953" @default.
- W2065864578 startingPage "937" @default.
- W2065864578 abstract "Recent experimental results suggest that the native fold, or topology, plays a primary role in determining the structure of the transition state ensemble, at least for small, fast-folding proteins. To investigate the extent of the topological control of the folding process, we studied the folding of simplified models of five small globular proteins constructed using a Go-like potential to retain the information about the native structures but drastically reduce the energetic frustration and energetic heterogeneity among residue-residue native interactions. By comparing the structure of the transition state ensemble (experimentally determined by Φ-values) and of the intermediates with those obtained using our models, we show that these energetically unfrustrated models can reproduce the global experimentally known features of the transition state ensembles and “en-route” intermediates, at least for the analyzed proteins. This result clearly indicates that, as long as the protein sequence is sufficiently minimally frustrated, topology plays a central role in determining the folding mechanism." @default.
- W2065864578 created "2016-06-24" @default.
- W2065864578 creator A5030987631 @default.
- W2065864578 creator A5061903235 @default.
- W2065864578 creator A5062809111 @default.
- W2065864578 date "2000-05-01" @default.
- W2065864578 modified "2023-10-17" @default.
- W2065864578 title "Topological and energetic factors: what determines the structural details of the transition state ensemble and “en-route” intermediates for protein folding? an investigation for small globular proteins" @default.
- W2065864578 cites W1487557334 @default.
- W2065864578 cites W1504780538 @default.
- W2065864578 cites W1526967281 @default.
- W2065864578 cites W1568658568 @default.
- W2065864578 cites W1584585216 @default.
- W2065864578 cites W1593625064 @default.
- W2065864578 cites W1593987163 @default.
- W2065864578 cites W1690887682 @default.
- W2065864578 cites W1969554454 @default.
- W2065864578 cites W1972464683 @default.
- W2065864578 cites W1974621200 @default.
- W2065864578 cites W1974862140 @default.
- W2065864578 cites W1977428203 @default.
- W2065864578 cites W1989110479 @default.
- W2065864578 cites W1990644981 @default.
- W2065864578 cites W1992783795 @default.
- W2065864578 cites W1993321394 @default.
- W2065864578 cites W1996679245 @default.
- W2065864578 cites W1996711229 @default.
- W2065864578 cites W1998072661 @default.
- W2065864578 cites W1999152484 @default.
- W2065864578 cites W2001199221 @default.
- W2065864578 cites W2002581599 @default.
- W2065864578 cites W2002967710 @default.
- W2065864578 cites W2004373243 @default.
- W2065864578 cites W2006501803 @default.
- W2065864578 cites W2008440654 @default.
- W2065864578 cites W2013247579 @default.
- W2065864578 cites W2014095962 @default.
- W2065864578 cites W2018187635 @default.
- W2065864578 cites W2020563037 @default.
- W2065864578 cites W2022196464 @default.
- W2065864578 cites W2022700790 @default.
- W2065864578 cites W2026101733 @default.
- W2065864578 cites W2026821880 @default.
- W2065864578 cites W2027095682 @default.
- W2065864578 cites W2027384625 @default.
- W2065864578 cites W2035266068 @default.
- W2065864578 cites W2037855582 @default.
- W2065864578 cites W2041721370 @default.
- W2065864578 cites W2044864889 @default.
- W2065864578 cites W2049043767 @default.
- W2065864578 cites W2049092553 @default.
- W2065864578 cites W2051039246 @default.
- W2065864578 cites W2051302860 @default.
- W2065864578 cites W2051714667 @default.
- W2065864578 cites W2053456517 @default.
- W2065864578 cites W2056528113 @default.
- W2065864578 cites W2056887931 @default.
- W2065864578 cites W2062064789 @default.
- W2065864578 cites W2064382750 @default.
- W2065864578 cites W2071075252 @default.
- W2065864578 cites W2071164291 @default.
- W2065864578 cites W2072261891 @default.
- W2065864578 cites W2074338740 @default.
- W2065864578 cites W2074848217 @default.
- W2065864578 cites W2076539319 @default.
- W2065864578 cites W2079687502 @default.
- W2065864578 cites W2080251754 @default.
- W2065864578 cites W2087517964 @default.
- W2065864578 cites W2088913827 @default.
- W2065864578 cites W2089211911 @default.
- W2065864578 cites W2089597488 @default.
- W2065864578 cites W2089685973 @default.
- W2065864578 cites W2098487677 @default.
- W2065864578 cites W2107100181 @default.
- W2065864578 cites W2110957877 @default.
- W2065864578 cites W2112032866 @default.
- W2065864578 cites W2129942180 @default.
- W2065864578 cites W2143416345 @default.
- W2065864578 cites W2144729032 @default.
- W2065864578 cites W2146606022 @default.
- W2065864578 cites W2158476854 @default.
- W2065864578 cites W2165222310 @default.
- W2065864578 cites W2171755502 @default.
- W2065864578 cites W3103544692 @default.
- W2065864578 cites W3104305066 @default.
- W2065864578 cites W4246527205 @default.
- W2065864578 doi "https://doi.org/10.1006/jmbi.2000.3693" @default.
- W2065864578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10801360" @default.
- W2065864578 hasPublicationYear "2000" @default.
- W2065864578 type Work @default.
- W2065864578 sameAs 2065864578 @default.
- W2065864578 citedByCount "1141" @default.
- W2065864578 countsByYear W20658645782012 @default.
- W2065864578 countsByYear W20658645782013 @default.
- W2065864578 countsByYear W20658645782014 @default.
- W2065864578 countsByYear W20658645782015 @default.
- W2065864578 countsByYear W20658645782016 @default.
- W2065864578 countsByYear W20658645782017 @default.