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- W2065881418 abstract "Defensins are naturally occurring antimicrobial peptides that disrupt bacterial membranes and prevent bacterial invasion of the host. Emerging studies indicate that certain defensins also block virus infection; however, the mechanism(s) involved are poorly understood. We demonstrate that human alpha-defensins inhibit adenovirus infection at low micromolar concentrations, and this requires direct association of the defensin with the virus. Moreover, defensins inhibit virus disassembly at the vertex region, thereby restricting the release of an internal capsid protein, pVI, which is required for endosomal membrane penetration during cell entry. As a consequence, defensins hamper the release of adenovirus particles from endocytic vesicles, resulting in virion accumulation in early endosomes and lysosomes. Thus, defensins possess remarkably distinct modes of activity against bacteria and viruses, and their function may provide insights for the development of new antiviral strategies." @default.
- W2065881418 created "2016-06-24" @default.
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- W2065881418 date "2008-01-01" @default.
- W2065881418 modified "2023-10-12" @default.
- W2065881418 title "Mechanism of Adenovirus Neutralization by Human α-Defensins" @default.
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- W2065881418 doi "https://doi.org/10.1016/j.chom.2007.12.001" @default.
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