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• W2065883713 endingPage "667" @default.
• W2065883713 startingPage "663" @default.
• W2065883713 abstract "microRNAs (miRNAs) are extensively involved in developmental programming. Some miRNAs are highly conserved, while others are lineage specific. All miRNAs maturate through a series of processing steps. Here we review recent progresses in the studies of early steps in miRNA biogenesis, focusing on animal systems. The miRNA maturation pathways are surprisingly diverse, involving transcription by RNA polymerase II or III, cleavage by the Drosha nuclease or the spliceosome, and sometimes modifications by the adenosine deaminase ADAR. The relationship between the diversity in miRNA biogenesis and the apparently rapid evolution of miRNA genes and functions is discussed." @default.
• W2065883713 created "2016-06-24" @default.
• W2065883713 creator A5005733972 @default.
• W2065883713 creator A5061511537 @default.
• W2065883713 date "2008-11-01" @default.
• W2065883713 modified "2023-09-26" @default.
• W2065883713 title "MicroRNA biogenesis: there's more than one way to skin a cat" @default.
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