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- W2065887316 abstract "The distribution and excretion was determined after the intravenous, oral, and dermal administration of [14C]- and [65Zn]zinc pyridinethione (ZPT) to rabbits. After intravenous administration, the 14C disappeared from the blood rapidly and within 6 hr, 75% was excreted into the urine while the concentration of 65Zn in the blood remained relatively constant and only 0.5% was excreted into the urine. The tissue concentrations of 65Zn were about 10 times higher than 14C 6 hr after administration, with 5% of the 14C remaining in the major organs and 55% of the 65Zn. After oral administration of ZPT, 45% of the 14C and 0.03% of the 65Zn was excreted into the urine within 6 hr. Eight hours after dermal application of ZPT, 0.5% of the 14C was excreted into the urine, and the same amount was found in the major organs of the rabbit. Less than 0.002% of the dermally applied 65Zn was found in the urine and 0.008% was found in the major organs. Therefore, this study demonstrates that the organic and inorganic portions of the molecule dissociate in their distribution and excretion from the body, the 14C portion is excreted from the body much more rapidly than the 65Zn. Both portions of the molecule can penetrate the skin to a limited extent, but the zinc portion does so less readily." @default.
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- W2065887316 title "Absorption, distribution, and excretion of zinc pyridinethione in rabbits" @default.
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- W2065887316 doi "https://doi.org/10.1016/0041-008x(76)90080-6" @default.
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