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- W2065893758 abstract "TO THE EDITOR: More than 80% of patients with acute hepatitis C develop chronic hepatitis (1, 2, 3). This high chronicity rate of acute hepatitis C provides a strong rationale for antiviral therapy during the acute course of the illness to avoid the progression toward chronic hepatitis. Many studies of therapy for acute hepatitis C have used interferon monotherapy, with sustained loss of hepatitis C virus (HCV)-RNA in 62% of interferon-treated patients, compared with only 12% in untreated subjects (4). There have been no studies of interferon–ribavirin combination therapy nor of the newly developed peginterferons. We report a case of a 20-yr-old woman without risk factors for acute HCV infection. She had been well until 2 months earlier, when asthenia developed. Physical examination was normal. Laboratory tests were performed: ASAT = 883 U/L, ALAT = 2289 U/L, alkaline phosphatase = 332 U/L, -glutamyl transpeptidase = 240 U/L. A test for antibodies to HIV, hepatitis B virus, cytomegalovirus, and Epstein-Barr virus were negative. A test for antibodies to HCV and HCV-RNA were positive. HCV genotype was 1b, and viral load was 22,500 copies of HCV-RNA 10-6/ml. We excluded other liver diseases." @default.
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- W2065893758 date "2003-09-01" @default.
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- W2065893758 title "Peginterferon and ribavirin in a patient with acute hepatitis C" @default.
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- W2065893758 doi "https://doi.org/10.1111/j.1572-0241.2003.07656.x" @default.
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