FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065903946> ?p ?o ?g. }

• W2065903946 endingPage "287" @default.
• W2065903946 startingPage "280" @default.
• W2065903946 abstract "The association oxaliplatin (OXA)-5-fluorouracil/folinic acid (FUFA) is currently a standard first-line treatment for advanced colorectal cancer. The main objective of this experimental study was to examine the cytotoxic effects resulting from the addition of ionizing radiation (Rgamma) to the combination OXA-FUFA on 2 human colon cancer cell lines (SW403, p53 wild type and WiDr, p53 mutated). A clinically relevant drug sequence was used consisting in OXA during 2 h followed by FUFA over 24 h. The impact of the position of radiation (1 and 4 Gy) was tested: radiation 2 h before drug application, in the middle of the drug application or 24 h after the drug application.Both cell lines exhibited similar dose response curves to Rgamma alone, WiDr being more radio-sensitive than SW403 (IC50: 4.8 Gy and 7 Gy, respectively). The effects of Rgamma-drug combinations were assessed using a conventional isobolographic method and by computing a potentiation factor (F) defined as the ratio of IC50 drug combinations/IC50 drug combinations combined with Rgamma. The results from both calculation methods concurred: the combination of OXA-FUFA with Rgamma led to additive-antagonistic effects for the p53 mutated cell line (WiDr), whatever the sequence. In contrast, for the p53 wild type cell line (SW403), additive-synergistic effects were observed with, in this case, an optimal position for Rgamma occurring when applied before or at mid-drug application.These results could be taken into consideration for an optimal design of clinical protocols associating Rgamma and OXA-FUFA." @default.
• W2065903946 created "2016-06-24" @default.
• W2065903946 creator A5001628805 @default.
• W2065903946 creator A5030092454 @default.
• W2065903946 creator A5046909112 @default.
• W2065903946 creator A5047469475 @default.
• W2065903946 creator A5055514871 @default.
• W2065903946 creator A5057842063 @default.
• W2065903946 creator A5075050232 @default.
• W2065903946 creator A5090050048 @default.
• W2065903946 date "2003-01-01" @default.
• W2065903946 modified "2023-10-18" @default.
• W2065903946 title "Oxaliplatin–5-Fluorouracil and Ionizing Radiation" @default.
• W2065903946 cites W1585172067 @default.
• W2065903946 cites W1641920546 @default.
• W2065903946 cites W1899767765 @default.
• W2065903946 cites W1981378981 @default.
• W2065903946 cites W2015159074 @default.
• W2065903946 cites W2023536833 @default.
• W2065903946 cites W2049131273 @default.
• W2065903946 cites W2077086851 @default.
• W2065903946 cites W2081927132 @default.
• W2065903946 cites W2097304119 @default.
• W2065903946 cites W2123136808 @default.
• W2065903946 cites W2171741749 @default.
• W2065903946 cites W2323577539 @default.
• W2065903946 cites W4233200910 @default.
• W2065903946 cites W4253331692 @default.
• W2065903946 doi "https://doi.org/10.1159/000069308" @default.
• W2065903946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12697970" @default.
• W2065903946 hasPublicationYear "2003" @default.
• W2065903946 type Work @default.
• W2065903946 sameAs 2065903946 @default.
• W2065903946 citedByCount "33" @default.
• W2065903946 countsByYear W20659039462012 @default.
• W2065903946 countsByYear W20659039462013 @default.
• W2065903946 countsByYear W20659039462015 @default.
• W2065903946 countsByYear W20659039462016 @default.
• W2065903946 countsByYear W20659039462018 @default.
• W2065903946 countsByYear W20659039462023 @default.
• W2065903946 crossrefType "journal-article" @default.
• W2065903946 hasAuthorship W2065903946A5001628805 @default.
• W2065903946 hasAuthorship W2065903946A5030092454 @default.
• W2065903946 hasAuthorship W2065903946A5046909112 @default.
• W2065903946 hasAuthorship W2065903946A5047469475 @default.
• W2065903946 hasAuthorship W2065903946A5055514871 @default.
• W2065903946 hasAuthorship W2065903946A5057842063 @default.
• W2065903946 hasAuthorship W2065903946A5075050232 @default.
• W2065903946 hasAuthorship W2065903946A5090050048 @default.
• W2065903946 hasConcept C111337013 @default.
• W2065903946 hasConcept C121332964 @default.
• W2065903946 hasConcept C121608353 @default.
• W2065903946 hasConcept C126322002 @default.
• W2065903946 hasConcept C18231593 @default.
• W2065903946 hasConcept C185544564 @default.
• W2065903946 hasConcept C2777752497 @default.
• W2065903946 hasConcept C2779804826 @default.
• W2065903946 hasConcept C2780035454 @default.
• W2065903946 hasConcept C2780962732 @default.
• W2065903946 hasConcept C502942594 @default.
• W2065903946 hasConcept C526805850 @default.
• W2065903946 hasConcept C54355233 @default.
• W2065903946 hasConcept C71924100 @default.
• W2065903946 hasConcept C81885089 @default.
• W2065903946 hasConcept C86803240 @default.
• W2065903946 hasConcept C98274493 @default.
• W2065903946 hasConceptScore W2065903946C111337013 @default.
• W2065903946 hasConceptScore W2065903946C121332964 @default.
• W2065903946 hasConceptScore W2065903946C121608353 @default.
• W2065903946 hasConceptScore W2065903946C126322002 @default.
• W2065903946 hasConceptScore W2065903946C18231593 @default.
• W2065903946 hasConceptScore W2065903946C185544564 @default.
• W2065903946 hasConceptScore W2065903946C2777752497 @default.
• W2065903946 hasConceptScore W2065903946C2779804826 @default.
• W2065903946 hasConceptScore W2065903946C2780035454 @default.
• W2065903946 hasConceptScore W2065903946C2780962732 @default.
• W2065903946 hasConceptScore W2065903946C502942594 @default.
• W2065903946 hasConceptScore W2065903946C526805850 @default.
• W2065903946 hasConceptScore W2065903946C54355233 @default.
• W2065903946 hasConceptScore W2065903946C71924100 @default.
• W2065903946 hasConceptScore W2065903946C81885089 @default.
• W2065903946 hasConceptScore W2065903946C86803240 @default.
• W2065903946 hasConceptScore W2065903946C98274493 @default.
• W2065903946 hasIssue "3" @default.
• W2065903946 hasLocation W20659039461 @default.
• W2065903946 hasLocation W20659039462 @default.
• W2065903946 hasOpenAccess W2065903946 @default.
• W2065903946 hasPrimaryLocation W20659039461 @default.
• W2065903946 hasRelatedWork W131030860 @default.
• W2065903946 hasRelatedWork W2010429874 @default.
• W2065903946 hasRelatedWork W2115083459 @default.
• W2065903946 hasRelatedWork W2171858932 @default.
• W2065903946 hasRelatedWork W2350264654 @default.
• W2065903946 hasRelatedWork W2394317145 @default.
• W2065903946 hasRelatedWork W2773636066 @default.
• W2065903946 hasRelatedWork W3048762836 @default.
• W2065903946 hasRelatedWork W4311343083 @default.
• W2065903946 hasRelatedWork W4362601064 @default.

• next