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• W2065905825 abstract "The metal chelators 1,10-phenanthroline and 2,9-dimethyl-1,10-phenanthroline (neocuproine) showed distinct abilities to prevent hydroxyl radical formation from hydrogen peroxide and Cu+ or F22+ (Fenton reaction) as determined by electron spin resonance. o-Phenanthroline prevented both Fe- and Cu-mediated Fenton reactions whereas neocuproine only prevented the Cu-mediate Fenton reaction. Because only 1,10-phenanthroline but not neocuproine prevented DNA strand-break formation in hydrogen peroxide-treated mammalian fibroblasts it appears that the Fe-mediated, as compared to the Cu-mediated, intranuclear Fenton reaction is responsible for DNA damage." @default.
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• W2065905825 date "1991-11-01" @default.
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• W2065905825 title "Iron is the intracellular metal involved in the production of DNA damage by oxygen radicals" @default.
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• W2065905825 doi "https://doi.org/10.1016/0027-5107(91)90220-i" @default.
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