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- W2065906720 abstract "Demonstrable penicillin levels in cerebrospinal fluid have been reported after intravenous or intramuscular administration only in patients who had inflammatory processes of meninges 1 or when penicillin was given by direct instillation. 2 Attainment of significant 3 penicillin activity in cerebrospinal fluid of patients who did not show evidence of meningeal involvement is not reported in available literature. McDermott and Nelson 4 and Mackie, 5 utilizing intramuscular doses as high as 500,000 Oxford units, failed to achieve significant cerebrospinal fluid concentration. Our own efforts, during past twenty-two months, after intramuscular doses of 20,000, 40,000 and 200,000 units have likewise been unsuccessful. Neymann, Heilbrunn and Youmans 6 recently concluded that intravenous and intramuscular methods of administration of penicillin were ineffective because the hematoencephalic barrier cannot be breached. We are presenting a series of cases in which significant levels of penicillin were obtained in" @default.
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- W2065906720 date "1946-02-09" @default.
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- W2065906720 title "PENICILLIN IN SPINAL FLUID AFTER INTRAVENOUS ADMINISTRATION" @default.
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- W2065906720 doi "https://doi.org/10.1001/jama.1946.02870060026006" @default.
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