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- W2065907157 abstract "<h3>Aim</h3> Neonatal lupus (NL) is a rare disease (1/12000–1/20000 newborns). It appears in the neonatal period of newborns of mothers with systemic lupus erythematosus (SLE) or other connective tissue diseases. It’s caused by the transfer of antibodies (Anti-Ro/Anti-La) from the mother to the fetus through the placenta. We recall the main features of the NL and the management of the child who have a mother with SLE. <h3>Methods</h3> We present 5 cases of mother-child diagnosed with SLE or NL. Four cases corresponds to mothers diagnosed with SLE (two or them, with children diagnosed of NL), and the other case is a NL with an asymptomatic mother without the diagnosis of SLE until this moment. <h3>Results</h3> Two or the four mothers diagnosed with SLE had children with NL (one with dermatologic clinic and the other with cardiac symptoms). These two mothers presented antibodies (Anti-Ro/Anti-La). The other two mothers didn’t present these antibodies, so they had healthy children. The fifth case was a newborn with a healthy mother, who was diagnosed with NL with dermatological features. After this, the mother was studied and had Anti-Ro/Anti-La antibodies. No child diagnosed of NL had blood or liver disorders. <h3>Conclusions</h3> We should study the children of mothers with SLE, particularly those with positive Anti-Ro/Anti-La antibodies, with the purpose of diagnosis of NL (particularly dermatological, cardiac, haematological and liver features). If we suspect NL in a child of an asymptomatic mother, the presence of Anti-Ro/Anti-La antibodies in the mother and the newborn should be studies to confirm the diagnosis." @default.
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- W2065907157 date "2012-10-01" @default.
- W2065907157 modified "2023-09-27" @default.
- W2065907157 title "1695 Mothers with Systemic Lupus Erythematosus and Neonatal Lupus. What you need to Know. A Presentation of 5 Cases" @default.
- W2065907157 doi "https://doi.org/10.1136/archdischild-2012-302724.1695" @default.
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