FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065921144> ?p ?o ?g. }

• W2065921144 endingPage "1117" @default.
• W2065921144 startingPage "1108" @default.
• W2065921144 abstract "Alpha-toxin (AT) is a major virulence factor in the disease pathogenesis of Staphylococcus aureus. We previously identified a monoclonal antibody (MAb) against AT that reduced disease severity in a mouse dermonecrosis model. Here, we evaluate the activity of an affinity-optimized variant, LC10, in a mouse model of S. aureus pneumonia. Passive immunization with LC10 increased survival and reduced bacterial numbers in the lungs and kidneys of infected mice and showed protection against diverse S. aureus clinical isolates. The lungs of S. aureus-infected mice exhibited bacterial pneumonia, including widespread inflammation, whereas the lungs of mice that received LC10 exhibited minimal inflammation and retained healthy architecture. Consistent with reduced immune cell infiltration, LC10-treated animals had significantly lower (P < 0.05) proinflammatory cytokine and chemokine levels in the bronchoalveolar lavage fluid than did those of the control animals. This reduction in inflammation and damage to the LC10-treated animals resulted in reduced vascular protein leakage and CO2 levels in the blood. LC10 was also assessed for its therapeutic activity in combination with vancomycin or linezolid. Treatment with a combination of LC10 and vancomycin or linezolid resulted in a significant increase (P < 0.05) in survival relative to the monotherapies and was deemed additive to synergistic by isobologram analysis. Consistent with improved survival, the lungs of animals treated with antibiotic plus LC10 exhibited less inflammatory tissue damage than those that received monotherapy. These data provide insight into the mechanisms of protection provided by AT inhibition and support AT as a promising target for immunoprophylaxis or adjunctive therapy against S. aureus pneumonia." @default.
• W2065921144 created "2016-06-24" @default.
• W2065921144 creator A5002656825 @default.
• W2065921144 creator A5012568736 @default.
• W2065921144 creator A5017557370 @default.
• W2065921144 creator A5025441513 @default.
• W2065921144 creator A5027959760 @default.
• W2065921144 creator A5038849475 @default.
• W2065921144 creator A5040103116 @default.
• W2065921144 creator A5049655890 @default.
• W2065921144 creator A5050859911 @default.
• W2065921144 creator A5051984080 @default.
• W2065921144 creator A5055566461 @default.
• W2065921144 creator A5059440505 @default.
• W2065921144 creator A5062016488 @default.
• W2065921144 creator A5078346266 @default.
• W2065921144 creator A5083919448 @default.
• W2065921144 creator A5085812977 @default.
• W2065921144 creator A5088256361 @default.
• W2065921144 creator A5091140160 @default.
• W2065921144 date "2014-02-01" @default.
• W2065921144 modified "2023-10-14" @default.
• W2065921144 title "Assessment of an Anti-Alpha-Toxin Monoclonal Antibody for Prevention and Treatment of Staphylococcus aureus-Induced Pneumonia" @default.
• W2065921144 cites W1884980943 @default.
• W2065921144 cites W1901785997 @default.
• W2065921144 cites W1918498545 @default.
• W2065921144 cites W1972039621 @default.
• W2065921144 cites W1974448472 @default.
• W2065921144 cites W1997339715 @default.
• W2065921144 cites W2003946063 @default.
• W2065921144 cites W2005388425 @default.
• W2065921144 cites W2008508169 @default.
• W2065921144 cites W2020710866 @default.
• W2065921144 cites W2023956656 @default.
• W2065921144 cites W2027017334 @default.
• W2065921144 cites W2032763818 @default.
• W2065921144 cites W2037816205 @default.
• W2065921144 cites W2040876125 @default.
• W2065921144 cites W2044206614 @default.
• W2065921144 cites W2050161704 @default.
• W2065921144 cites W2065283067 @default.
• W2065921144 cites W2066137456 @default.
• W2065921144 cites W2066879967 @default.
• W2065921144 cites W2071502670 @default.
• W2065921144 cites W2072842693 @default.
• W2065921144 cites W2074827635 @default.
• W2065921144 cites W2084046310 @default.
• W2065921144 cites W2093754560 @default.
• W2065921144 cites W2098375088 @default.
• W2065921144 cites W2104120081 @default.
• W2065921144 cites W2106939286 @default.
• W2065921144 cites W2112652622 @default.
• W2065921144 cites W2116854552 @default.
• W2065921144 cites W2121045183 @default.
• W2065921144 cites W2121159475 @default.
• W2065921144 cites W2121448090 @default.
• W2065921144 cites W2122714192 @default.
• W2065921144 cites W2125066910 @default.
• W2065921144 cites W2126467473 @default.
• W2065921144 cites W2135191756 @default.
• W2065921144 cites W2137736234 @default.
• W2065921144 cites W2139293168 @default.
• W2065921144 cites W2140383372 @default.
• W2065921144 cites W2142732953 @default.
• W2065921144 cites W2144370711 @default.
• W2065921144 cites W2146171215 @default.
• W2065921144 cites W2147978858 @default.
• W2065921144 cites W2150244847 @default.
• W2065921144 cites W2150491739 @default.
• W2065921144 cites W2151770040 @default.
• W2065921144 cites W2160104568 @default.
• W2065921144 cites W2163107191 @default.
• W2065921144 cites W2163305262 @default.
• W2065921144 cites W2164248238 @default.
• W2065921144 cites W2170283209 @default.
• W2065921144 cites W2172160601 @default.
• W2065921144 cites W2468632781 @default.
• W2065921144 cites W4214754383 @default.
• W2065921144 doi "https://doi.org/10.1128/aac.02190-13" @default.
• W2065921144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3910899" @default.
• W2065921144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24295977" @default.
• W2065921144 hasPublicationYear "2014" @default.
• W2065921144 type Work @default.
• W2065921144 sameAs 2065921144 @default.
• W2065921144 citedByCount "144" @default.
• W2065921144 countsByYear W20659211442014 @default.
• W2065921144 countsByYear W20659211442015 @default.
• W2065921144 countsByYear W20659211442016 @default.
• W2065921144 countsByYear W20659211442017 @default.
• W2065921144 countsByYear W20659211442018 @default.
• W2065921144 countsByYear W20659211442019 @default.
• W2065921144 countsByYear W20659211442020 @default.
• W2065921144 countsByYear W20659211442021 @default.
• W2065921144 countsByYear W20659211442022 @default.
• W2065921144 countsByYear W20659211442023 @default.
• W2065921144 crossrefType "journal-article" @default.
• W2065921144 hasAuthorship W2065921144A5002656825 @default.
• W2065921144 hasAuthorship W2065921144A5012568736 @default.

• next