FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065925053> ?p ?o ?g. }

• W2065925053 endingPage "115" @default.
• W2065925053 startingPage "110" @default.
• W2065925053 abstract "Abstract Background Several studies have suggested that Langerhans cell histiocytosis (LCH) is responsive to treatment with bisphosphonates (BPs). However the efficacy and safety of BPs therapy for childhood LCH is unknown. Procedure Data on children with LCH who had received BPs therapy were collected retrospectively from hospitals participating in the Japanese Pediatric Leukemia/Lymphoma Study Group. Results Twenty‐one children with histologically proven LCH were identified. Of these, the case histories of 16 children who had been treated with pamidronate (PAM) for disease reactivation were analyzed in detail. The median post‐PAM therapy follow‐up period was 2.8 years (range: 0.9–9.3 years). The median age at commencement of PAM therapy was 9.4 years (range: 2.3–15.0 years). All children had one or more bone lesions but none had risk organ (RO) involvement. In the majority of the children, six courses of PAM were administered at a dose of 1.0 mg/kg/course at 4‐week intervals. In 12 of the 16 children, all active lesions including lesions of the skin (n = 3) and soft tissues (n = 3) resolved. Of these children, eight children had no active disease for a median of 3.3 years post‐PAM therapy (range: 1.8–9.3 years). Progression‐free survival (PFS) was 56.3 ± 12.4% at 3 years. PFS was significantly higher in children with a first reactivation compared with children experiencing a second or subsequent reactivation. Conclusions PAM may be an effective treatment for reactivated LCH with bone lesions. A prospective trial of the efficacy of PAM in recurrent pediatric LCH is warranted. Pediatr Blood Cancer. 2010;56:110–115. © 2010 Wiley‐Liss, Inc." @default.
• W2065925053 created "2016-06-24" @default.
• W2065925053 creator A5001385905 @default.
• W2065925053 creator A5002554232 @default.
• W2065925053 creator A5007864049 @default.
• W2065925053 creator A5010042672 @default.
• W2065925053 creator A5014119862 @default.
• W2065925053 creator A5022557754 @default.
• W2065925053 creator A5029680324 @default.
• W2065925053 creator A5038653989 @default.
• W2065925053 creator A5043584280 @default.
• W2065925053 creator A5044883471 @default.
• W2065925053 creator A5047091160 @default.
• W2065925053 creator A5054966180 @default.
• W2065925053 creator A5080395160 @default.
• W2065925053 creator A5084323300 @default.
• W2065925053 creator A5085706107 @default.
• W2065925053 creator A5086694128 @default.
• W2065925053 creator A5091820922 @default.
• W2065925053 date "2010-11-24" @default.
• W2065925053 modified "2023-10-17" @default.
• W2065925053 title "Nationwide survey of bisphosphonate therapy for children with reactivated Langerhans cell histiocytosis in Japan" @default.
• W2065925053 cites W102145721 @default.
• W2065925053 cites W1964052241 @default.
• W2065925053 cites W1968626722 @default.
• W2065925053 cites W1975118167 @default.
• W2065925053 cites W1981128885 @default.
• W2065925053 cites W1983427347 @default.
• W2065925053 cites W1990412304 @default.
• W2065925053 cites W2018809551 @default.
• W2065925053 cites W2018821675 @default.
• W2065925053 cites W2023658695 @default.
• W2065925053 cites W2025672294 @default.
• W2065925053 cites W2040153285 @default.
• W2065925053 cites W2043377701 @default.
• W2065925053 cites W2048162835 @default.
• W2065925053 cites W2052140198 @default.
• W2065925053 cites W2056698396 @default.
• W2065925053 cites W2061373199 @default.
• W2065925053 cites W2069596065 @default.
• W2065925053 cites W2074065079 @default.
• W2065925053 cites W2078626081 @default.
• W2065925053 cites W2084293321 @default.
• W2065925053 cites W2101111540 @default.
• W2065925053 cites W2101375269 @default.
• W2065925053 cites W2126838017 @default.
• W2065925053 cites W2135262186 @default.
• W2065925053 cites W2135981033 @default.
• W2065925053 cites W2153194157 @default.
• W2065925053 cites W2198240143 @default.
• W2065925053 cites W2313031960 @default.
• W2065925053 cites W2338266297 @default.
• W2065925053 cites W4211062787 @default.
• W2065925053 cites W4256653765 @default.
• W2065925053 doi "https://doi.org/10.1002/pbc.22703" @default.
• W2065925053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21108445" @default.
• W2065925053 hasPublicationYear "2010" @default.
• W2065925053 type Work @default.
• W2065925053 sameAs 2065925053 @default.
• W2065925053 citedByCount "30" @default.
• W2065925053 countsByYear W20659250532012 @default.
• W2065925053 countsByYear W20659250532013 @default.
• W2065925053 countsByYear W20659250532014 @default.
• W2065925053 countsByYear W20659250532015 @default.
• W2065925053 countsByYear W20659250532016 @default.
• W2065925053 countsByYear W20659250532017 @default.
• W2065925053 countsByYear W20659250532018 @default.
• W2065925053 countsByYear W20659250532019 @default.
• W2065925053 countsByYear W20659250532020 @default.
• W2065925053 countsByYear W20659250532021 @default.
• W2065925053 countsByYear W20659250532022 @default.
• W2065925053 countsByYear W20659250532023 @default.
• W2065925053 crossrefType "journal-article" @default.
• W2065925053 hasAuthorship W2065925053A5001385905 @default.
• W2065925053 hasAuthorship W2065925053A5002554232 @default.
• W2065925053 hasAuthorship W2065925053A5007864049 @default.
• W2065925053 hasAuthorship W2065925053A5010042672 @default.
• W2065925053 hasAuthorship W2065925053A5014119862 @default.
• W2065925053 hasAuthorship W2065925053A5022557754 @default.
• W2065925053 hasAuthorship W2065925053A5029680324 @default.
• W2065925053 hasAuthorship W2065925053A5038653989 @default.
• W2065925053 hasAuthorship W2065925053A5043584280 @default.
• W2065925053 hasAuthorship W2065925053A5044883471 @default.
• W2065925053 hasAuthorship W2065925053A5047091160 @default.
• W2065925053 hasAuthorship W2065925053A5054966180 @default.
• W2065925053 hasAuthorship W2065925053A5080395160 @default.
• W2065925053 hasAuthorship W2065925053A5084323300 @default.
• W2065925053 hasAuthorship W2065925053A5085706107 @default.
• W2065925053 hasAuthorship W2065925053A5086694128 @default.
• W2065925053 hasAuthorship W2065925053A5091820922 @default.
• W2065925053 hasConcept C126322002 @default.
• W2065925053 hasConcept C141071460 @default.
• W2065925053 hasConcept C187212893 @default.
• W2065925053 hasConcept C2777484599 @default.
• W2065925053 hasConcept C2779134260 @default.
• W2065925053 hasConcept C2780174970 @default.
• W2065925053 hasConcept C71924100 @default.
• W2065925053 hasConceptScore W2065925053C126322002 @default.

• next